Voorbereiding NSAIDs Flashcards

(30 cards)

1
Q

Salicylic acid derivatives

A

Acetylsalicylic acid (aspirin), sulphosalazine

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2
Q

Indole and indene acetic acids

A

Indomethacin, etodolac, sulindac

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3
Q

Hetero-aryl acetic acids

A

Diclofenac, ketorolac, tolmetin

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4
Q

Aryl-propionic acids

A

Ibuprofen, ketoprofen, flurbiprofen, naproxen, fenoprofen

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5
Q

Anthranilic acids (fenamates)

A

Mefenamic acid, meclofenamic acid

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6
Q

Enolic acids (oxicams)

A

Piroxicam, tenoxicam, meloxicam

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7
Q

Alkanones

A

Nabumetone

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8
Q

Diarylheterocycles (selective COX-2 inhibitors, coxibs)

A

Celecoxib, rofecoxib, etoricoxib

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9
Q

Pyrazolone derivatives

A

Antipyrine, dipyrone, propyphenazone

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10
Q

Para-aminophenol derivates

A

Acetaminophen (paracetamol)

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11
Q

Sulphonanilide derivatives

A

Nimesulide

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12
Q

Acetylsalicylic acid (aspirin), sulphosalazine

A

Salicylic acid derivatives

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13
Q

Indomethacin, etodolac, sulindac

A

Indole and indene acetic acids

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14
Q

Diclofenac, ketorolac, tolmetin

A

Hetero-aryl acetic acids

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15
Q

Ibuprofen, ketoprofen, flurbiprofen, naproxen, fenoprofen

A

Aryl-propionic acids

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16
Q

Mefenamic acid, meclofenamic acid

A

Anthranilic acids (fenamates)

17
Q

Piroxicam, tenoxicam, meloxicam

A

Enolic acids (oxicams)

18
Q

Nabumetone

19
Q

Celecoxib, rofecoxib, etoricoxib

A

Diarylheterocycles (selective COX-2 inhibitors, coxibs)

20
Q

Antipyrine, dipyrone, propyphenazone

A

Pyrazolone derivatives

21
Q

Acetaminophen (paracetamol)

A

Para-aminophenol derivates

22
Q

Nimesulide

A

Sulphonanilide derivatives

23
Q

Preferentially inhibit COX-1

A

Fenoprofen, Flurbiprofen, Ketoprofen, Oxaprozin, Tolmetin (discontinued in the United States)

24
Q

Nonselective NSAIDs

A

Ibuprofen, Indomethacin, Ketorolac, Nabumetone, Naproxen, Piroxicam, Sulindac

25
NSAIDs with lower COX-2 selectivity
Celecoxib, Diclofenac, Etodolac, Mefenamic acid, Meloxicam, Nimesulide (not available in the United States), Salsalate
26
NSAIDs with higher COX-2 selectivity
Etoricoxib (not available in the United States), Lumiracoxib (withdrawn worldwide), Rofecoxib (withdrawn worldwide), Valdecoxib (withdrawn worldwide)
27
Fenoprofen, Flurbiprofen, Ketoprofen, Oxaprozin, Tolmetin (discontinued in the United States)
Preferentially inhibit COX-1
28
Ibuprofen, Indomethacin, Ketorolac, Nabumetone, Naproxen, Piroxicam, Sulindac
Nonselective NSAIDs
29
Celecoxib, Diclofenac, Etodolac, Mefenamic acid, Meloxicam, Nimesulide (not available in the United States), Salsalate
NSAIDs with lower COX-2 selectivity
30
Etoricoxib (not available in the United States), Lumiracoxib (withdrawn worldwide), Rofecoxib (withdrawn worldwide), Valdecoxib (withdrawn worldwide)
NSAIDs with higher COX-2 selectivity