[W8] Transfusion science Flashcards
(18 cards)
What is SABRE?
Reporting system for serious adverse blood reactions/events.
Which agency inspects blood establishments in the UK?
MHRA
When is platelet transfusion indicated?
For bleeding prevention/treatment in thrombocytopenia or platelet dysfunction.
What is FFP used for?
Replacing clotting factors, especially in TTP or liver disease.
What gene is essential for ABO antigen expression?
H (FUT1) gene
What is the most antigenic Rh antigen?
D
What is Rhnull?
No RhD or CE proteins; associated with mild haemolytic anaemia.
What blood group phenotype is protective against malaria?
Fy(a-b-)
What causes McLeod syndrome?
Kx protein deficiency (X-linked)
Which antibody type causes acute intravascular haemolysis?
IgM (e.g., ABO mismatch)
What type of haemolysis is IgG-mediated?
Extravascular (delayed)
What antibody causes the most severe HDN?
Anti-D
What test checks for fetal RBCs in maternal blood?
Kleihauer test
What is given to prevent anti-D formation in pregnancy?
Anti-D immunoglobulin at 28 weeks and after delivery.
What is TRALI?
Transfusion-Related Acute Lung Injury – caused by donor anti-leukocyte antibodies.
What is Post-Transfusion Purpura (PTP)?
Severe thrombocytopenia due to anti-HPA antibodies ~5–12 days post-transfusion.
What is TA-GVHD?
Graft-vs-host disease from donor lymphocytes in immunocompromised recipients.
How is TA-GVHD prevented?
Irradiation of blood products.
