Weak Chemical Interaction: The Heart of Molecular Genetics Flashcards Preview

GN 421 > Weak Chemical Interaction: The Heart of Molecular Genetics > Flashcards

Flashcards in Weak Chemical Interaction: The Heart of Molecular Genetics Deck (14):
1

Covalent bonds

- peptide
- glycosidic
- phosphodiester
- very strong

2

weak bonds

- non-covalent bonds
- easily broken and reformed to allow a specific interaction between and within biological macromolecules (DNA, RNA, and proteins) to be formed and readily changed

3

major types of weak chemical interactions

1. Van der Waals forces
2. Hydrogen bonds
3. Ionic bonds
4. Hydrophobic interactions

4

Strength of interactions

- Covalent > Ionic > Hydrogen > Hydrophobic
- bond energies for weak bonds much lower than for non covalent bonds and can easily be made and broken.

5

Combined versus Uncombined

- ratio between combined and uncombined molecules

6

if ratio is high

- strong bond
- combined

7

if ratio low

- weak bond
- uncombined

8

Higher Delta G

- more reactants in combined form rather than uncombined form.

9

small difference in bond energy

- BIG difference in ratio of combined and uncombined components.

10

A good fit is necessary

- a large # of simultaneous interactions
- dependent on distance and angles of interaction (geometry)

11

The Law of Mass Action Applies

- amount of combined vs uncombined dependent upon total concentration

12

if low concentration

more likely to be uncombined

13

if high concentration

will be more likely to interact with each other - combined

14

hydrophobic interactions

- Van der Waals forces, hydrogen bonds, and ionic bonds are responsible for RECOGNITION AND SPECIFICITY.
- But the DRIVING FORCE (the most important consideration in the overall STRENGTH of interaction between two macromolecules) is the HYDROPHOBIC INTERACTION