Week 146 - Aortic Stenosis Flashcards Preview

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Flashcards in Week 146 - Aortic Stenosis Deck (29):

What valves are closing when the first heart sound is produced?

Atrio-ventricular valves (Tricuspid and mitral)


What valves are closing when the sound heart sound is heart?

The aortic and pulmonary valves


What stage of the heart cycle is signified by the first heart sound?

The beginning of systole


What stage of the heart cycle is signified by the second heart sound?

The beginning of diastole


Which part of the heart cycle is shortened when the heart rate increases, and what is a consequence of this?

Diastole, means that a very fast beating heart does not remain relaxed enough to allow complete filling of the ventricles before the next contraction


How much of the ventricular filling is caused by atrial contraction?

Around 20% - the remaining 80% is filled by direct blood flow from the SVC and IVC through the atria into the ventricles


On the JVP waveform, what causes the a, c and v waves?

a wave:

  • Atrial contraction

c wave:

  • Beginning of ventricular contraction as the tricupsid valve bulges back into the right atrium

v wave:

  • End of ventricular contraction when blood is entering the atria but the tricupsid valve is still shut


On the JVP waveform what causes the x and y descents?

x descent:

  • Contraction of the ventricles, the blood empties from the ventricles so the tricupsid valve no longer bulges into the atrium

y descent:

  • Opening of the tricuspid valve, allowing blood to flow from the atria to the ventricles


What occurs during the period of rapid ventricular filling?

The pressure in the atria is higher than the diastolic ventricles so the AV valves open allowing blood to flow rapidly into the ventricles and lasts about 1/3 the length of diastole



What is the period of isovolumetric contraction?

It is immediately after the beginning of ventricular contraction where the sharp rise in ventricular pressure causes the AV valves to close.

There is then a period of increasing pressure due to ventricular contraction but the pressure is not enough to open the aortic and pulmonary valves.



What pressures must be inside the ventricles to open the aortic and pulmonary valves?

Aortic valve - >80mmHg

Pulmonary valve - > 8mmHg


Which 1/3 of systole does the majority of blood get ejected from the heart, and what is this period called?

The first 1/3 (70% of the ventricular volume is ejected)

Called the period of rapid ejection


Describe the period of isovolumetric relaxation

The sudden onset of ventricular relaxation allows the ventricular pressures to drop rapidly.

The larger pressures in the arteries push blood back towards this lower pressure, causing the semilunar valves to snap shut.

During this period, the intraventricular pressures decrease rapidly back to their low diastolic pressures.


How much blood is normally found within each ventricle at the end of diastole, and what is this volume called?

Around 110-120mL per ventricle

Called the end-diastolic volume


How much blood is pumped out each ventricle during diastole and what name is given to this measurement?

Around 70mL

This is known as the stroke volume output


How much blood is left in each ventricle at the end of systole and what is this called?

Around 40-50mL

Known as the end systolic volume


What is the ejection fraction?

The fraction of the end-diastolic volume that is ejected from the heart - usually around 60%


What 2 mechanisms can be used to increase the stroke volume output?

Increase the end-diastolic volume - increase blood flow into the ventricles

Decrease the end-systolic volume - strong heart contraction


What is the most common cause of aortic stenosis?

Calcific aortic valvular disease


What are the risk factors for calcific aortic valvular disease?

Old age


Elevated lipoprotein and LDL





What is the process of calcific aortic valvular disease?

Subendothelial thickening with adjacent fibrosis, which may contain lipoproteins and then calcify, increasing the stiffness of the valve


What other conditions are associated with a bicuspid valve?

Aortic coarctation

Root dilatation

Aortic dissection


What infection is associated with aortic stenosis, usually with mitral valve disease

Rheumatic fever caused by Steptococcus pyogenes


What are some differential diagnoses for aortic stenosis?

Supravalvular narrowing

Subvalvular diaphragm or ridge

Hypertrophic cardiomyopathy


What is the triad of symptoms associated with aortic stenosis?





What clinical signs are seen with aortic stenosis?


  • Sinus rhythm, slow rising pulse, low volume

Aortic area:

  • Systolic thrill


  • Not displaced, sustained


  • Ejection click; A2, S4


  • Systolic, low pitched, ejection and radiates to carotids


What findings might be seen on a CXR of a patient with aortic stenosis?

  • Relatively small heart with prominent, dilated ascending aorta - post stenotic dilatation
  • Calcification of the aortic valve



What ECG changes may be seen in aortic stenosis?

Signs of LV hypertrophy and L atrial delay

Left ventricular strain pattern - Depressed ST segment and T wave inversion in 1, aVL, V5 and V6