Week 2 Flashcards
(47 cards)
Rapidly progressive (Crescentic) glomerulonephritis : Type __: Anti GBM- Idiopathic more than __% of the time. Good pastures syndrome: Characterized by development of autoimmune aggression against __ and __ basement membranes. Antibodies form against antigens of membranes. Type __ hypersensitivity reaction.
1 50 Glomerular alveolar 2
Good Pasture’s: Alveolar basement membrane- ___ (coughing up blood) Inflammation of this membrane causes the formation of ___ in the __ and they can no longer exchange ___
Hemoptysis
exudates
alveoli
air
Good Pasture’s: Glomerular basement membrane- here there is destruction of __ around the membranes. This is curable via ___. Blood from the arterioles is centrifuged and the blood cells are removed from the ___ in the plasma then reinjected into the body. Involves which 2 systems?
tissues plasmapheresis antibodies Respiratory kidneys
Rapidly Progressive (Crescentic) Glomerulonephritis: Type 2 (Immune complex deposition): Systemic Lupus Erythematosus- Type __ Hypersensitivity reaction: Classic AI disease that involves young ladies and is more common in __ __. What are some causes?
3 African Americans Sulfasalysitic Drugs Vaccination UV radiation
Rapidly Progressive (Crescentic) Glomerulonephritis: Type 2 (Immune complex deposition) Systemic Lupus Erythematosus: AI reaction against antigens of __ and __. Mostly involves the __(4)__
cell nucleus cytoplasm Skin Lungs Kidney Cerebral Vessels
Rapidly Progressive (Crescentic) Glomerulonephritis: Type 2 (Immune complex deposition) Systemic Lupus Erythematosus: results in serious ___ and possibly ___. Primary manifestation of systemic lupus is the __ __.
HTN
stroke
butterfly rash
Systemic Lupus Erythematosus: Systemic Lupus: Involvement of the __ develops quickly. This is the major cause of death in this disease. Vasculitis of __ vessels is possible in SLE. Survival is __% of the time. Tx is __ (corticosteroid)
kidneys
cerebral
90
TMT
Systemic Lupus Erythematosus: Post Infection may be part of type __. Henoch Schonlein Purpura- ( ___ vasulitis)- usually develops in ___.
2
Hemorrhagic
Boys (in 20s)
Henoch Schonlein is characterized by what 4 syndromes?
Abdominal Syndrome
Cutaneous Syndrome
Articular Syndrome
Crescentic Glomerulonephritis
Abdominal syndrome is characterized by __ __ of the __ and __ walls (gastroduodenitis)
hemorrhagic inflammation
stomach
duodenal
Cutaneous Syndrome is characterized by __ hemorrhages in the __ and __- leads to __ rash
cutaneous
buttock
abdomen
purpura
Articular syndrome is characterized by __ __ or at least __ in the __
subclinical arthritis
pain
joints
Crescentic glomerulonephritis: If the pt has the 1st 3 syndromes, the addition of crescentic glomerular nephritis makes the prognosis worse: __% survival
70
Type 3 Rapidly Progressive (Crescentic) Glomerulonephritis: MOST DANGEROUS: Type __ Hypersensitivity reaction- Is characterized by the development of ___. It is inflammation of the vasular wall and manifested by what kind of antibodies?
NO Hypersensitivity reaction
vasculitis
anti-neutrophil plasmocytic auto-antibodies
Type 3 Rapidly Progressive (Crescentic) Glomerulonephritis: What are the 5 types?
Idiopathic (more than 50%) Wegener's Granulomatosus Polyarteritis Nodosa IgA Nephropathy (AKA Berger's) Buerger's (AKA Thromboangitis Obliterans)
Type 3 Rapidly Progressive (Crescentic) Glomerulonephritis: Wegener’s Granulomatosus: Develops in middle aged __. Characterized by necrotizing vasculitis of the upper and lower __ tract and rapid progression of __. You see a melting of the __ of the __ which can lead to __ and __ inflammation. Pt is undergoing decay.
Males Respiratory Glomerulonephritis bones face infection supprative
Type 3 Rapidly Progressive (Crescentic) Glomerulonephritis: Wegener’s Granulomatosus: What will the pt. die from?
Acute renal failure or secodary complications
Type 3 Rapidly Progressive (Crescentic) Glomerulonephritis: Polyarteritis Nodosa: vasculitis of the vessels throughout the body with __ of the arteriole wall, which gives it the name nodosa. Pouching can lead to __ of the wall and __ of the lumen. These nodes are on every __ of the body and causes __. This disease can manifest everywhere but where?
pouching rupture obstruction organ death -Lungs and arch of Aorta
*incurable
Type 3 Rapidly Progressive (Crescentic) Glomerulonephritis: IgA Nephropathy (Berger’s): ___ following __ __ infection. Many cases month after month. Could also be cause by acute __ or __ infection. Pt will experience pain in the __.
Hematuria acute respiratory intestinal urinary loin (lumbar spine)
Type 3 Rapidly Progressive (Crescentic) Glomerulonephritis: IgA Nephropathy (Berger’s): Hallmark is deposition of __ complexes into the immune mesangium. (__% increase). There will also be increased concentration of IgA in the __. Can manifest with __ __ __. If not controlled can switch to __ __
IgA 50 Blood Henoch-Schonlein Purpura Chronic Glomerulonephritis
What is the most common glomerular disease worldwide?
Berger’s (IgA Nephropathy)
Type 3 Rapidly Progressive (Crescentic) Glomerulonephritis: Buerger Disease: Characterized by vaculitis of the __ and __ sized arteries. Predominant in __ and __ arteries. If it is in the veins will cause __. Will cause inflammation of the __.
middle small Radial Tibial phlebitis veins
Type 3 Rapidly Progressive (Crescentic) Glomerulonephritis: Buerger Disease: Common in people who __ and common in which countries? Characterized by __ syndrome and smoking. Will cause instep claudication- __ on walking, then will stop, walk more, stop again, etc… The muscles need more __ supply but they aren’t getting enough because of vessel dysfunction. Results in __ of extremities.
smoke India and Israel Raynaud's Pain blood amputation
Nephrotic Syndrome: Damage to __. There is decreased permeability of __ and draatically increased permeability of __ (primary probem), especially __. Escape from the blood to the urine.
glomeruli
water
protein
albumin
