Week 238 - Heart Failure Flashcards

1
Q

Week 238 - Heart Failure: What are the CXR signs of heart failure?

A
  • Caridomegaly
  • Upper zone vessel enlargement - A sign of pulmonary venous hypertension.
  • Pulmonary oedema - Bat-wing shape of increased lung-markings.
  • Kerley B lines.
  • Pleural effusions.
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2
Q

Week 238 - Heart Failure: What are Kerley B lines?

A
  • These are specific radiographic signs of pulmonary oedema.

* Small horizontal lines along the lateral borders of the lung fields.

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3
Q

Week 238 - Heart Failure: What is the management of renal deterioration?

A
  • Stop furosemide.
  • Decrease statins.
  • Commence isosorbide mononitrate and later hydralazine which are both vasodilators.
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4
Q

Week 238 - Heart Failure: When someone has features of both left and right sided heart failure they are said to have what?

A

Congestive cardiac failure.

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5
Q

Week 238 - Heart Failure: What is the presentation of Right sided heart failure?

A
  • Oedema and ascites.
  • Liver congestion - Impaired liver function.
  • GI tract congestion - Anorexia, GI distress, Weight loss.
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6
Q

Week 238 - Heart Failure: What is the presentation of Left heart failure?

A
  • Decreased cardiac output - Activity intolerance, Cyanosis, signs of hypoxia.
  • Pulmonary congestion - Othropnoea, Cough with frothy sputum, Paroxysmal nocturnal dyspnoea.
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7
Q

Week 238 - Heart Failure: What are the SIGNS of right-sided heart failure?

A
  • Anorexia
  • Increased JVP
  • Ascites
  • GI distress
  • Sacral oedema
  • Dependent oedema
  • Hepato/splenomegaly
  • Fatigue
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8
Q

Week 238 - Heart Failure: What are the SIGNS of left-sided heart failure?

A
  • Coughs, Crackles, Wheeze, PND, Orthopnoea, Tachypnoea
  • Cyanosis and hypocia
  • Frothy white sputum
  • Exertional dyspnoea
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9
Q

Week 238 - Heart Failure: What is the difference between systolic and diastolic heart failure?

A

Both are left-sided!
• Systolic - Insufficient contraction (E.g. post-MI)
• Diastolic - Insufficient relaxation

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10
Q

Week 238 - Heart Failure: What is the NYHA classification of heart failure?

A
  • Class 1 - Cardiac disease, but ordinary exercise does not cause undue fatigue, palpitation, dyspnoea or anginal pain.
  • Class 2 - Cardiac disease with a slight limitation on exercise but are comfortable at rest.
  • Class 3 - Cardiac disease with marked limitation on exercise but are comfortable at rest.
  • Class 4 - Cardiac disease with inability to carry out any physical activity without discomfort. Symptoms may be present at rest.
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11
Q

Week 238 - Heart Failure: What is the definition of acute heart failure?

A

A rapid change in the onset or change in symptom and signs of heart failure - Life-threatening.
- Often see in decompensation of a patient with chronic HF.

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12
Q

Week 238 - Heart Failure: How do people with acute heart failure usually present?

A

• Pulmonary oedema, cardiogenic shock or increasing dyspnoea.

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13
Q

Week 238 - Heart Failure: What is the general management of someone with acute heart failure?

A
  • Admission to monitored area.
  • Key drugs: Oxygen, diuretics and vasodilators.
  • Non-invasive ventilation may be needed.
  • Monitor: HR + rhythm, BP, Sats, urine output.
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14
Q

Week 238 - Heart Failure: In which situation should oxygen be administered in acute heart failure? What is the problem with using inappropriately?

A

• Use if Sp02

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15
Q

Week 238 - Heart Failure: What is the specific management of acute left ventricular failure?

A
  • Oxygen
  • Diamorphine 2.5mg IV
  • Metoclopramide 10 mg, IV
  • Furosemide 40-80mg, IV
  • IV nitrates
  • Consider non-invasive/mechanical ventilation.
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16
Q

Week 238 - Heart Failure: In the case of an acute on chronic heart failure situation, what diuretic may need to be added to furosemide?

A

Metolazone (thiazide-like)

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17
Q

Week 238 - Heart Failure: Which type of diuretic is ideal for the use with acute and chronic heart failure? Why?

A

Loop-diuretics - Furosemide.

• More potent diuresis and act quicker and last for a shorter time than thiazides.

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18
Q

Week 238 - Heart Failure: How do thiazides work?

A

• Act at the beginning of the distal convoluted tubule to inhibit Na+ reabsorption.

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19
Q

Week 238 - Heart Failure: How do loop diuretics work?

A

As it says on the tin, they act on the loop of Henle by inhibiting Na+ reabsorption.

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20
Q

Week 238 - Heart Failure: What are the side-effects of thiazide (and related) diuretics?

A
  • Electrolyte disturbance - reduced Na+ and K+
  • Increased risk of gout due to increased urate.
  • Hyperglycaemia.
  • Deranged lipids.
21
Q

Week 238 - Heart Failure: Give some examples of thiazide diuretics.

A
  • Bendroflumethiazide
  • Chlortalidone
  • Hydrochlorothiazide
  • Metolazone
  • Indapamide
22
Q

Week 238 - Heart Failure: What role do opiates play in the treatment of acute heart failure?

A
  • Relieve anxiety and distress due to dyspnoea.

* Venodilators

23
Q

Week 238 - Heart Failure: How do vasodilators help in heart-failure?

A

Reduce preload, afterload and increases stroke volume.

24
Q

Week 238 - Heart Failure: Nitroglycerine is a vasodilator used in treatment of heart-failure, however it does not relieve dyspnoea. Which vasodilator does?

A

Nesiritide.

25
Week 238 - Heart Failure: Once acute heart failure has been stabilised what is the medication used?
ACE-inhibitor | Beta blocker
26
Week 238 - Heart Failure: In NYHA class II-IV which three drug classes are strongly recommended for therapeutic use?
* ACE-I * Beta blocker * Mineralocorticoid receptor antagonist
27
Week 238 - Heart Failure: In which patients are ACE-I indicated for?
All those with a left-ventricular ejection fraction of
28
Week 238 - Heart Failure: How do ACE-I improve pre-load and after load?
* ACE-I reduce the breakdown of Bradykinin. (along with effect of ATII) * Bradykinin is an inflammatory mediator which leads to vasodilation. * This vasodilation is why pre-load and after-load are reduced.
29
Week 238 - Heart Failure: Which ACE-I is still frequently used in paediatric cardiology?
Captopril
30
Week 238 - Heart Failure: What are the contraindications for use of an ACE-I?
* Severe aortic stenosis, mitral stenosis, Left-ventricular outflow obstruction * Bilateral renal artery stenosis * Pregnancy * History of idiopathic/hereditary angioedema * Creatine >220umol/l
31
Week 238 - Heart Failure: Give examples of some Angiotensin II receptor antagonists.
* Candesartan * Valsartan * Erpotsartan * Losartan
32
Week 238 - Heart Failure: What should be used instead of ACEI/ARBs if they are not tolerated?
Isosobide dinitrate and hydralazine. (Along with Beta-blocker,digoxin,aldosterone antagonist) (If still symptomatic)
33
Week 238 - Heart Failure: What is the role of aldosterone antagonism in treatment of heart failure?
• Added to conventional therapies in order to suppress aldosterone levels - cardioprotective.
34
Week 238 - Heart Failure: In which patients are aldosterone antagonists indicated?
• Severe symptomatic heart failure (grade III/IV) with LVEF
35
Week 238 - Heart Failure: What do alpha-receptor agonists do? (Vascular)
• Constrict vessels - Increases Total peripheral resistance - Increases central venous pressure > Decreases cardiac output
36
Week 238 - Heart Failure: What are the main contraindications of beta-blockers?
* Asthma / COPD * Cardiac conduction defects. * Severe heart failure * Severe peripheral vascular disease * Raynaud's disease
37
Week 238 - Heart Failure: Which beta-blockers have specifically been show to be helpful in heart failure?
* Bisoprolol * Carvedilol * Metoprolol * Nebivilol
38
Week 238 - Heart Failure: Which beta-blocker is used in pregnancy and is used as an IV infusion for the rapid control of BP?
• Labetolol
39
Week 238 - Heart Failure: What is Ivabradine?
It inhibits the If(funny) channel in the sinus node, thereby slowing the heart rate in sinus rhythm. - Has been shown to reduce hospitalisation in HF patients.
40
Week 238 - Heart Failure: Why do you get oedema in heart failure?
Increases in venous pressure and GFR causes salt and water retention.
41
Week 238 - Heart Failure: What are the common causes of heart failure?
* IHD * Hypertension * Valvular heart disease * Cardiomyopathy * Toxic - alcohol * Diabetes
42
Week 238 - Heart Failure: What are the main causes of right heart failure?
* Chronic lung disease * Pulmonary hypertension * Left to right intra cardiac shunts * Chronic valvular heart disease
43
Week 238 - Heart Failure: What is cardiac cachexia?
Weight loss and anorexia commonly seen in heart failure. | - Due to metabolic changes, gut congestion, reduced intake and inflammatory causes.
44
Week 238 - Heart Failure: Which of the types of left-sided heart failure has a normal ejection fraction?
Diastolic
45
Week 238 - Heart Failure: What are the differential diagnoses for high output heart failure?
* Anaemia * Septicaemia * Liver-failure * Beri-beri * Thyrotoxicosis * Paget's disease * AV shunt
46
Week 238 - Heart Failure: The increase of which substances in the blood may indicate myocardial wall stress?
* B-type natriuretic peptide (BNP) | * N-terminal pro-BNP
47
Week 238 - Heart Failure: What may you see on an echocardiogram that would suggest heart failure?
* Dilated LV/RV * Reduced LV/RD contractility * Valve lesions
48
Week 238 - Heart Failure: What are the surgical options for treatment of heart failure?
Depends on the underlying cause. - Revascularisation - CABG and PCI - Treatment of valvular heart disease
49
Week 238 - Heart Failure: What changes occur during auscultation of the heart in heart failure?
Third heart sound - gallop rhythm