What is the process that allows cell division to progress to the M-phase? Flashcards by Keeran Kirupakaran

Q

What happens in G1 phase?

A

For cells to divide and proliferate, cyclin D is first synthesised to activate Cdk4/6 in order for cells to pass the R-point
Cyclin E levels increase and activates Cdk2

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Q

What happens in S phase?

A

E-Cdk2 activates cyclin A-Cdk2 which is required for DNA replication in S-phase

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Q

What happens in G2 phase?

A

Cyclin A-Cdk2 ensure Cyclin B-Cdk1 becomes active, and acts to allow cell to progress to M-phase

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