XXIII - The Nervous System (with pics) Flashcards Preview

Topnotch Patho Flash Cards 2016 > XXIII - The Nervous System (with pics) > Flashcards

Flashcards in XXIII - The Nervous System (with pics) Deck (213)
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211

Alzheimer-related lesions. PLAQUE or TANGLE: Bundles of paired helical filaments visible as basophilic fibrillary structures. A major component is an abnormally hyperphosphorylated TAU protein. Not specific for Alzheimer's.

Tangle. SEE SLIDE 23.11. (TOPNOTCH)Robbins Basic Pathology, 9th ed., p 838

212

In Parkinson's Disease, where are Lewy bodies appear first?

Interesingly, it appears first in the medulla, and then the pons, before involvement of the substantia nigra. (M>P>S in alphabetical order) (TOPNOTCH)Robbins Basic Pathology, 9th ed., p 839

213

Often located midline in the cerebellum in children, and lateral in adults. On histology, lesion is extremely cellular with sheets of anaplastic (small blue) cells.

Medulloblastoma (TOPNOTCH)Robbins Basic Pathology, 9th ed., p 845