08.20 - Tx of Viral Lung Infection (Sweatman) - Questios Flashcards Preview

Pulmonology > 08.20 - Tx of Viral Lung Infection (Sweatman) - Questios > Flashcards

Flashcards in 08.20 - Tx of Viral Lung Infection (Sweatman) - Questios Deck (39):
1

Which drugs are not metabolized

Amantadine, Zanamavir

2

Hx of Illness that suggest viral vs bacterial cause

Slow onset - Viral; Rapid - Bacterial

3

CRP conc. that suggests viral vs bacterial cause

Less than 20mg/L Viral - Greater than 60mg/L Bacterial

4

Tx of RSV

Ribavirin

5

MOA of Amantadine

Viral entry or uncoating

6

Tx of Enterovirus

None

6

MOA of Zanamivir

Release of influenza from infected cell

7

MOA of Rimantadine

Viral entry or uncoating

7

Neutropenia

Acyclovir, Valacyclovir

9

Tx of Influenza A and B

Osetamivir, Zanamivir

10

Tx of Rhinovirus

None

11

Orthostatic Hypotension

Amantadine

12

Toxicities of Amantadine

Neuro, Orthostatic Hypotension

13

Tx of Influenza A only

Amantadine, Rimantadine

14

Clinical profiles that suggest viral vs bacterial cause

Viral - Rhinitis, Wheezing; Bacterial - Fever, Tachypnea

14

Black box warning for Hemolytic Anemia and M/F Teratogenicity

Ribavirin

15

Toxicities of Oseltamavir

Minimal

15

Toxicities of Rimantadine

Minimal

15

Black box warning for renal impairment/toxicity

Cidofovir

16

Toxicities of Ribavirin

Black box for hemolytic anemia and M/F teratogenicity

18

MOA of Oseltamavir

Release of influenza from infected cell

19

CXR findings that suggest viral vs bacterial cause

Viral - Sole interstitial infiltrates bilaterally; Bacterial - Lobar alveolar infiltrates

20

Tx of Varicella-Zoster Virus

Acyclovir, Valacyclovir

22

MOA of Cidofovir

DNA polymerase inhibition

23

MOA of Acyclovir

DNA polymerase inhibition

24

WBC Count that suggests viral vs bacterial cause

Less than 10x19^9 Viral - Greater than 15x10^9 Bacterial

25

Toxicities of Cidofovir

Black box for renal impairment/toxicity

27

Toxicities of Acyclovir

Neutropenia, Renal precipitation

28

Which drugs are hepatically metabolized

Oseltamavir, Rimantadine, Valacyclovir

29

Tx of Adeno

Cidofovir

29

Renal Precipitation

Acyclovir, Valacyclovir

30

Tx of Human Metapneumovirus

Ribavirin

32

Toxicities of Zanamavir

Don't use with pulmonary disease - Fatal Bronchospasm

34

Tx of Hantavirus

Ribavirin

35

Can cause fatal bronchospasm

Zanamavir

36

MOA of Ribavirin

Viral nucleic acid synthesis

37

MOA of Valacyclovir

Pro-drug for acyclovir - DNA polymerase inhibition

38

Which drugs are CYP substrates

Oseltamavir(?), Rimantadine(?)

39

Toxicities of Valacyclovir

Neutropenia, Renal precipitation