08.20 - Tx of Viral Lung Infection (Sweatman) - Questios

Question 1

Which drugs are not metabolized

Answer 1

Amantadine, Zanamavir

Question 2

Hx of Illness that suggest viral vs bacterial cause

Answer 2

Slow onset - Viral; Rapid - Bacterial

Question 3

CRP conc. that suggests viral vs bacterial cause

Answer 3

Less than 20mg/L Viral - Greater than 60mg/L Bacterial

Question 4

Tx of RSV

Answer 4

Ribavirin

Question 5

MOA of Amantadine

Answer 5

Viral entry or uncoating

Question 6

Tx of Enterovirus

Answer 6

None

Question 6

MOA of Zanamivir

Answer 6

Release of influenza from infected cell

Question 7

MOA of Rimantadine

Answer 7

Viral entry or uncoating

Question 7

Neutropenia

Answer 7

Acyclovir, Valacyclovir

Question 9

Tx of Influenza A and B

Answer 9

Osetamivir, Zanamivir

Question 10

Tx of Rhinovirus

Answer 10

None

Question 11

Orthostatic Hypotension

Answer 11

Amantadine

Question 12

Toxicities of Amantadine

Answer 12

Neuro, Orthostatic Hypotension

Question 13

Tx of Influenza A only

Answer 13

Amantadine, Rimantadine

Question 14

Clinical profiles that suggest viral vs bacterial cause

Answer 14

Viral - Rhinitis, Wheezing; Bacterial - Fever, Tachypnea

Question 14

Black box warning for Hemolytic Anemia and M/F Teratogenicity

Answer 14

Ribavirin

Question 15

Toxicities of Oseltamavir

Answer 15

Minimal

Question 15

Toxicities of Rimantadine

Answer 15

Minimal

Question 15

Black box warning for renal impairment/toxicity

Answer 15

Cidofovir

Question 16

Toxicities of Ribavirin

Answer 16

Black box for hemolytic anemia and M/F teratogenicity

Question 18

MOA of Oseltamavir

Answer 18

Release of influenza from infected cell

Question 19

CXR findings that suggest viral vs bacterial cause

Answer 19

Viral - Sole interstitial infiltrates bilaterally; Bacterial - Lobar alveolar infiltrates

Question 20

Tx of Varicella-Zoster Virus

Answer 20

Acyclovir, Valacyclovir

Question 22

MOA of Cidofovir

Answer 22

DNA polymerase inhibition

Question 23

MOA of Acyclovir

Answer 23

DNA polymerase inhibition

Question 24

WBC Count that suggests viral vs bacterial cause

Answer 24

Less than 10x19^9 Viral - Greater than 15x10^9 Bacterial

Question 25

Toxicities of Cidofovir

Answer 25

Black box for renal impairment/toxicity

Question 27

Toxicities of Acyclovir

Answer 27

Neutropenia, Renal precipitation

Question 28

Which drugs are hepatically metabolized

Answer 28

Oseltamavir, Rimantadine, Valacyclovir

Question 29

Tx of Adeno

Answer 29

Cidofovir

Question 29

Renal Precipitation

Answer 29

Acyclovir, Valacyclovir

Question 30

Tx of Human Metapneumovirus

Answer 30

Ribavirin

Question 32

Toxicities of Zanamavir

Answer 32

Don't use with pulmonary disease - Fatal Bronchospasm

Question 34

Tx of Hantavirus

Answer 34

Ribavirin

Question 35

Can cause fatal bronchospasm

Answer 35

Zanamavir

Question 36

MOA of Ribavirin

Answer 36

Viral nucleic acid synthesis

Question 37

MOA of Valacyclovir

Answer 37

Pro-drug for acyclovir - DNA polymerase inhibition

Question 38

Which drugs are CYP substrates

Answer 38

Oseltamavir(?), Rimantadine(?)

Question 39

Toxicities of Valacyclovir

Answer 39

Neutropenia, Renal precipitation