08.21 - Histamine (Sweatman) - Questions Flashcards Preview

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Flashcards in 08.21 - Histamine (Sweatman) - Questions Deck (47)
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1

2 major sites of Histamine Biosynthesis

Mast Cells, Basophils

2

Enzyme that catalyzes Histamine Biosynthesis

L-Histidine Decarboxylase

3

3 Notable Activators of Histamine Synthesis and Release

GM-CSF, IL-3, Peptides

4

2 Notable inhibitors of Histmaine Synthesis and Release

Beta-antagonists; Cromolyn

5

3 Notable Histamine Activating Factors

Gastrin, Ca2+, Vancomycin

6

Ig isotype that causes Histamine

IgE

7

Cytokine that stimulates B cell to produce IgE

IL-4

8

Cytokine that stimulates TH1 to release IFN-g

IL-12

9

Release of histamine from granule matrix occurs by __ exchange

Cation

10

What percent of Mast Cell Granule does Histamine compose?

10%

11

Major actions of H1 receptors

SM contraction; Stim of NO formation; Endothelial cell contraction; Incr vascular permeability

12

Major actions of H2 receptors

Simulation of gastric acid secretion

13

Major actions of H3 receptors

Inhibition of NT release

14

Mediator of H2 signaling

AC --> cAMP --> Decr Ca2+, SIRS, PG --> Extracellular

15

Mediator of H1 signaling

GD --> cGMP --> PG, EDRF --> Extracellular

16

Histamine receptors in lung

H1 - Bronchoconstrict; H2 - Bronchodilation

17

Histamine receptors in heart

H1 - Slow AV conduction; H2 - Enhanced constraction

18

Histamine receptors in vasculature

H1, H2 - Microvasodilation; H1 - Permeability, Vasoconstriction

19

Histamine receptors in neural tissue

H1, H3 - Nerve ending stim, wakefullness and sedation

20

Histamine effects on capillaries

No effect

21

Histamine effects on venules

H1 - Rapid onset short term dilation (cap permeability); H2 - Slow onset persisent dilation

22

Histamine effects on Veins

H1 - Constriction of SM, Dilation of Endo; H2 - Dilation of SM

23

Histamine effects on Arteries

H1 - Constriction of SM, Dilation of Endo; H2 - Dilation of SM

24

Histamine effects on Arterioles

H1 - Rapid onset short term dilation; H2 - Slow onset persistent dilation

25

Effect of Mast Cells and Basophils on Mucus Glands

Diarrhea, Rhinorrhea, Bronchial secretion

26

Effect of Mast Cells/Basophils on Sensory Nerves

Itching

27

Advantages of Second Gen Anti-histamines

Longer, Fewer doses, Non-sedating, Limited anti-cholinergic

28

3 Notable Side Effects of 1st Gen H1-Antags

Impaired cognition, Dystonia, Nasal Congestion

29

1st gen with highest anti-cholinergic

Phenothiazines (promethazine)

30

1st gen with highest sedative effect

Phenothiazines (promethazine)

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