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Pulmonology > 08.21 - Cough Suppression, Decongestants, Mucolytics (Malik) - Questions > Flashcards

08.21 - Cough Suppression, Decongestants, Mucolytics (Malik) - Questions Flashcards

(55 cards)

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1
Q

Clear sputum =

A

Bronchitis

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2
Q

Purulent sputum =

A

Bronchial Infection

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3
Q

Yellow sputum =

A

Inflammatory Disorders

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4
Q

Maladorous Sputum =

A

Anaerobic Infection

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5
Q

Antitussives for non-productive coughs

A

Dextro, Diphenhydramine, Codeine, Camphor, Menthol

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6
Q

DOC for productive coughs with thick secretions

A

Guaifenesin (expectorant)

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7
Q

Antitussives with direct effect on cough center

A

Dextro, Diphenhydramine, Codeine

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8
Q

Action and Metabolism of Dextro

A

Direct inhibition of cough center; CYP2D6

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9
Q

Contraindications for Dextro

A

MOAi, Advanced Respiratory insufficiency, Hepatic Disease

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10
Q

Diphenhydramine is indicated for

A

Nonproductive cough caused by irritation (2nd line agent)

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11
Q

Action of Diphenhydramine

A

H1 receptor antagonist; Direct suppression of cough center - Anti-cholinergic

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12
Q

Action of Codeine

A

Opioid analgesic, acts on mu receptors; Direct inhibition of cough center

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13
Q

Side Effects of Codeine

A

Histamine Release, Vasodilation

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14
Q

Contraindications of Codeine

A

Pregnancy; Respiratory depression

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15
Q

Topic Anti-tussives for non-productive cough

A

Camphor, Menthol, Eucalyptus

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16
Q

Only FDA approved expectorant

A

Guaifenesin

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17
Q

Side Effects of Guaifenesin

A

Uric Acid Nephrolithiasis (large doses)

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18
Q

Contraindication to Guaifenesin

A

Hypersenstivity

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19
Q

Action of Guaifenesin

A

Increases volume and reduces viscosity of secretions

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20
Q

Guaifenesin is not used for

A

Chronic Cough

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21
Q

Congestion is due to

A

Dilation of blood vessels - Histamine and inflammatory mediators cause vessel dilation

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22
Q

Afferent receptor nerves are carried to

A

Nucleus Tractus Solitarus

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23
Q

No __ to blood vessels, no ___ to mucus glands

Study These Flashcards
A

Para, Sympathetic

24
Q

Phenylephrine is a selective

Study These Flashcards
A

Alpha1-Agonist

25
Nasal Decongestants do not affect release of ___
Histamine - So commonly formulated with anti-histamines
26
2 Oral Decongestants
Pseudoephedrine, Phenylephrine
27
Pseudoephedrine acts primarily by ___, while PE acts by ___
Releasing NE, while PE directly stimulates alpha-adrenergic receptors
28
PE is metabolized by
MOA and COMT
29
Side effect profiles of Systemic Decongestants
CV Stimulation; CNS stimulation. Children and elderly more likely to experience
30
Who is more likely to experience side effects from Systemic Decongestants
Children and elderly
31
Which Decongestant causes reflex bradycardia
Phenylephrine
32
Contraindications of systemic decongestants
Bradycardia, Partial Heart Block
33
Spray Decongestants
Oxymetazoline and PE
34
Action of Oxymetazoline
Alpha1-agonist
35
Preferred topical decongestant in pregnancy
Oxymetazoline
36
Advantages of decongestant drops
Small children
37
Decongestant Inhalers
Levamfetamine and Propylhexadrine
38
Action of Levamfetamine
Stimulates NE release
39
Action of Propylhexadrine
Indirectly activates NE receptors
40
3 Expectorants
Iodinated Glycerol; Bromohexine; Guiafenesin
41
At high doses, Guiafenesin stimulates
bronchial gland secretion
42
Action of Bromohexine
Incr production of serous mucuous to decr viscosity of phlegm
43
Function of Bland Aerosols
Diliute mucus molecule
44
5 Mucolytics
N-Acetyl Cysteine; Sodium Bicarb; Dornate Alfa; Amiloride; Denufosol Tetrasodium
45
Action of N-Acetyl Cysteine
Break bonds of mucus
46
Side Effects of N-Acetyl Cysteine
Bronchospasm, Incr mucus production
47
Action of Sodium Bicarb
Incr pH of mucus
48
What is Dornase Alfa
rhDNAase
49
Action of Dornase Alfa
Reduce viscosity of secretions by breakin gdown extracellular DNA
50
Indications fo Dornase Alfa
CF, CB, Bronchiectasis
51
Contraindications of Dornase Alfa
Chinese Hamster Ovary Cell products
52
Side effects of Dornase Alfa
Voice alteration, Chest pain
53
Action of Amiloride
Diuretic (Na channel blocker) given to CF patients to prevent dehydration of mucus
54
Diuretic (Na channel blocker) given to CF patients to prevent dehydration of mucus
Amiloride
55
Action of Denufosol Tetrasodium
Activates Cl secretion and inhibits Na transport (P2Y2 receptor activation) --> Mucosal hhydration and clearance

Pulmonology (31 decks)

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