08.18 - Asthma (Muthiah) - Questions Flashcards Preview

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Flashcards in 08.18 - Asthma (Muthiah) - Questions Deck (26):
1

T/F: All airway remodeling in Asthma is permanent

False, some is reversible

2

Treatment of Mild Persistent Asthma

Inhaled steroids

3

Tx of Moderate Persistent Asthma

Inhaled steroids and LABA's

4

Tx of Severe Persistent Asthma

Inhaled steroids, LABA's, Leukotriene Modifiers

5

Most common type of asthma

Extrinsic

6

IgE in Intrinsic Asthma

Non-allergic: Serum IgE not elevated (as much)

7

Skin antigen test in Intrinsic Asthma

Usually negative

8

Family Hx in Extrinsic vs Intrinsic

Positive in extrinsic usually, Non-contributory in intrinsic

9

Samter's Syndrome

Asthma, Aspirin Sensitivity, Nasal Polyps

10

When does exercise-induced bronchospasm occur

5-10 minutes after exercise

11

Pathophys of Exercise-Induced

Cooling and mucosal drying of airways triggers mast cell release of histamine

12

Pre-treatment of Exercise-induced

Beta-agonist or Cromolyn

13

What is Cromolyn

Mast cell membrane-stabilizing agent (can't degranulate)

14

Why is nocturnal asthma common between midnight and 8am

Decline of circulating catecholamines and cortisol

15

Type of response/reaction in ABPA

IgE-mediated reaction; Type 3 IgE-mediated response

16

Distinguishing features of ABPA

Very elevated eosinophilia; Very high IgE; Fleeting chest infiltrates

17

Mainstay tx of ABPA

Prednison (Anti-fungals don't improve mortality)

18

Origin of Major Basic Protein

Eosinophils

19

Where does fibrosis occur in remodeling

Subepithelial

20

Relevant Interleukins in Asthma vs COPD

IL-5 in Asthma; IL-8 in COPD

21

Asthma vs COPD: Neutrophilic vs Eosinophilic during exacerbation

Asthma is Neutrophilic; COPD is Eosinophilic (contrary to primary inflammatory cell)

22

3 signs of life threatening asthma

Accessory muscle use; Hypoxemia; Hypercapnea

23

Death from asthma is usually related to

Diffuse mucous plugging of airways

24

What is considered diagnostic on Peak Flow Meter

Diurnal varation of PEFR >20%

25

DLCO in Asthma

Normal (occassionally elevated)

26

Why should we use LABA's cautiously

Associated with increased mortality