08.18 - Asthma (Muthiah) - Questions Flashcards Preview

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Flashcards in 08.18 - Asthma (Muthiah) - Questions Deck (26)
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1
Q

T/F: All airway remodeling in Asthma is permanent

A

False, some is reversible

2
Q

Treatment of Mild Persistent Asthma

A

Inhaled steroids

3
Q

Tx of Moderate Persistent Asthma

A

Inhaled steroids and LABA’s

4
Q

Tx of Severe Persistent Asthma

A

Inhaled steroids, LABA’s, Leukotriene Modifiers

5
Q

Most common type of asthma

A

Extrinsic

6
Q

IgE in Intrinsic Asthma

A

Non-allergic: Serum IgE not elevated (as much)

7
Q

Skin antigen test in Intrinsic Asthma

A

Usually negative

8
Q

Family Hx in Extrinsic vs Intrinsic

A

Positive in extrinsic usually, Non-contributory in intrinsic

9
Q

Samter’s Syndrome

A

Asthma, Aspirin Sensitivity, Nasal Polyps

10
Q

When does exercise-induced bronchospasm occur

A

5-10 minutes after exercise

11
Q

Pathophys of Exercise-Induced

A

Cooling and mucosal drying of airways triggers mast cell release of histamine

12
Q

Pre-treatment of Exercise-induced

A

Beta-agonist or Cromolyn

13
Q

What is Cromolyn

A

Mast cell membrane-stabilizing agent (can’t degranulate)

14
Q

Why is nocturnal asthma common between midnight and 8am

A

Decline of circulating catecholamines and cortisol

15
Q

Type of response/reaction in ABPA

A

IgE-mediated reaction; Type 3 IgE-mediated response

16
Q

Distinguishing features of ABPA

A

Very elevated eosinophilia; Very high IgE; Fleeting chest infiltrates

17
Q

Mainstay tx of ABPA

A

Prednison (Anti-fungals don’t improve mortality)

18
Q

Origin of Major Basic Protein

A

Eosinophils

19
Q

Where does fibrosis occur in remodeling

A

Subepithelial

20
Q

Relevant Interleukins in Asthma vs COPD

A

IL-5 in Asthma; IL-8 in COPD

21
Q

Asthma vs COPD: Neutrophilic vs Eosinophilic during exacerbation

A

Asthma is Neutrophilic; COPD is Eosinophilic (contrary to primary inflammatory cell)

22
Q

3 signs of life threatening asthma

A

Accessory muscle use; Hypoxemia; Hypercapnea

23
Q

Death from asthma is usually related to

A

Diffuse mucous plugging of airways

24
Q

What is considered diagnostic on Peak Flow Meter

A

Diurnal varation of PEFR >20%

25
Q

DLCO in Asthma

A

Normal (occassionally elevated)

26
Q

Why should we use LABA’s cautiously

A

Associated with increased mortality

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