08.26 - Lung Cancer (Nichols) - Questions Flashcards Preview

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Flashcards in 08.26 - Lung Cancer (Nichols) - Questions Deck (80)
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1

What percentage of heavy smokers get lung cancer

11%

2

What percentages of lung cancer do the 3 most common make?

Adeno 40%, Squamous 20%, Small Cell 15%

3

Location of Adeno, Squamous, and Small Cell

Peripheral, Central, Central

4

Which is most commonly associated with paraneoplastic?

Small Cell

5

Which is most associated with post-obstructive pneumonia

Squamous

6

Which is most associated with hypercalcemia

Squamous

7

Median age at presenation for all

70

8

In which types is cough more common

Squamous and Small Cell because central

9

Small Cell is typically treated by

Chemotherapy, unless limited to chest and mediastinal lymph nodes (add radiation)

10

__ for EGFR mutation

Erlotinib

11

Erlotinib

EGFR mutation

12

Crizotinib

Translocated ALK

13

Targets translocated ALK

Crizotinib

14

70% of nonsmokers with lung cancer have

Adenocarcinoma

15

In Adenocarcinoma, often mutations in ___ in never-smokers and ___ in smokers

EGFR-dependent pathway in never-smokers, KRAS-dependent pathway in smokers

16

KRAS mutations confer resistance to

Erlotinib

17

Type most likely to be responsive to targeted therapy

Adenocarcinoma

18

4 Gross Path features of Adeno

Peripheral, Solitary, Infiltrate pleura, Spiculated

19

Most common micro type of Adeno

Acinar

20

Adeno types with poor prognosis

Micropapillary, Solid

21

Adeno types with good prognosis

Lepidic

22

Treatment for Adenocarcinoma

Surgery if low stage, Targeted (Erlotinib, Crizotinib), Radiation + Double Chemo if inoperable

23

Adenocarcinomas are more likely to have ___ mutations and almost never have __ mutations

EGFR, KRAS

24

Adeno in Situ is characterized by

Non-destructive growth along intact alveolar septa (lepidic growth)

25

2 Types of Adeno In Situ and Pathogenesis

Non-mucinous from terminal respiratory unit cells (EGFR); Mucinous from Bronchiolar Epithelium (KRAS)

26

Gross Path of Adeno In Situ

Single or Multifocal Nodules, or pneumonia-like consolidation

27

Micro Path of Adeno In Situ

Replaces alveolar lining

28

Symptoms and Signs of Adeno In Situ

majority have none

29

Tx of Adeno In Situ

Surgery; Erlotinib or Crizotinib if applicable; Chemo

30

Two defining features of Squamous Cell

Keratinization and/or Intracellular Bridges

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