Flashcards in 08.26 - Lung Cancer (Nichols) - Questions Deck (80)
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1
What percentage of heavy smokers get lung cancer
11%
2
What percentages of lung cancer do the 3 most common make?
Adeno 40%, Squamous 20%, Small Cell 15%
3
Location of Adeno, Squamous, and Small Cell
Peripheral, Central, Central
4
Which is most commonly associated with paraneoplastic?
Small Cell
5
Which is most associated with post-obstructive pneumonia
Squamous
6
Which is most associated with hypercalcemia
Squamous
7
Median age at presenation for all
70
8
In which types is cough more common
Squamous and Small Cell because central
9
Small Cell is typically treated by
Chemotherapy, unless limited to chest and mediastinal lymph nodes (add radiation)
10
__ for EGFR mutation
Erlotinib
11
Erlotinib
EGFR mutation
12
Crizotinib
Translocated ALK
13
Targets translocated ALK
Crizotinib
14
70% of nonsmokers with lung cancer have
Adenocarcinoma
15
In Adenocarcinoma, often mutations in ___ in never-smokers and ___ in smokers
EGFR-dependent pathway in never-smokers, KRAS-dependent pathway in smokers
16
KRAS mutations confer resistance to
Erlotinib
17
Type most likely to be responsive to targeted therapy
Adenocarcinoma
18
4 Gross Path features of Adeno
Peripheral, Solitary, Infiltrate pleura, Spiculated
19
Most common micro type of Adeno
Acinar
20
Adeno types with poor prognosis
Micropapillary, Solid
21
Adeno types with good prognosis
Lepidic
22
Treatment for Adenocarcinoma
Surgery if low stage, Targeted (Erlotinib, Crizotinib), Radiation + Double Chemo if inoperable
23
Adenocarcinomas are more likely to have ___ mutations and almost never have __ mutations
EGFR, KRAS
24
Adeno in Situ is characterized by
Non-destructive growth along intact alveolar septa (lepidic growth)
25
2 Types of Adeno In Situ and Pathogenesis
Non-mucinous from terminal respiratory unit cells (EGFR); Mucinous from Bronchiolar Epithelium (KRAS)
26
Gross Path of Adeno In Situ
Single or Multifocal Nodules, or pneumonia-like consolidation
27
Micro Path of Adeno In Situ
Replaces alveolar lining
28
Symptoms and Signs of Adeno In Situ
majority have none
29
Tx of Adeno In Situ
Surgery; Erlotinib or Crizotinib if applicable; Chemo
30
