1 - Anatomy & Histology of the Liver Flashcards Preview

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Flashcards in 1 - Anatomy & Histology of the Liver Deck (73)
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1

Normal Liver Mass

1500g
Largest organ

2

Normal Portal Pressure

5 - 10 mm Hg
Low pressure

3

Hepatocytes - Do they all do the same thing?

No!!!!
They have functional heterogeneity

4

Liver's borders

Right 5th rib
Left 6th rib
Right 9th rib

Feel it below the 9th rib and it's HUGE!!!!!!

5

Contents of the portal vein

Collection of venous blood from spleen, splenic vein, SMA, IMA

6

Portal Hypertension

Obstruction to portal vein flow causing pressure to increase above 10mm Hg

7

Post-Hepatic Hypertension

Rarest kind of portal HTN

Congenital webs of the IVC

8

Intra-Hepatic Hypertension

Most common type of portal HTN

Cirrhosis
Other types of pathology

9

Pre-Hepatic Hypertension

Thrombosis blocking entry to the portal vein

10

How many lobes?

2!

11

Components of the liver

2 Lobes
Glisson's Capsule (smooth! IT IS SMOOTH!!)
Falciform Ligament

12

Real divisions of the liver

8 Segments
4 on the left, 4 on the right
Each has its own vascular and biliary pedacle

13

Two sources of blood for the liver

Celiac Trunk > Hepatic Artery > Left & Right Lobes
Splenic Vein + IMA + SMA > Portal Vein

14

Biliary Tree

Bile conducted from ducts inside into common hepatic duct which meets with cystic duct to join the GI tract

15

Lobule

One functional unit of hepatocytes.
Central vein in the center
Arterial flow at the periphery
No connective tissue divisions between lobules the way pigs do!!!

16

Central veins

Marked by venous endothelium

17

Portal tracts

Collagen tracts that carry 3 tubes:

Bile duct
Artery
Vein

Can fibrose in pathways leading to other portal tracts when inflammation fucks that shit up

18

Blood path through a lobule

Portal tracts at periphery
Contents flow through sinudoids in the periportal regions
Undergo hella changes
Enter central veins to go back to the heart.

19

Bile Cannaliculi

Collect bile, interanastomose and form the canal of herring, which drains into the individual bile ducts that drain into the hilum and the common bile duct.

20

Where do the progenitor (stem) cells in the liver live?

The Canal of Herring

21

Description of Lobule

Radiating Cords
Nicely organized
Once Cell Thick (so nicely bathed)

22

Central Veins

Anastomose into Hepatic Veins (R & L)
Exit to IVC

23

Portal Tract on Histo

Nothing but collagen, fibroblasts and triad of structures
Inflammatory

24

Bile Duct

Tube of cuboidal epithelium

25

Limiting Plate

The hepatocytes at the edge of the Portal Tract
Chronic Hepatitis - Lymphocytes and inflammatory cells can infiltrate this structure and cause fibrosis

26

Mixing of Portal Venous and Hepatic Arterial Blood

Hepatic artery branches give off small twigs which empty arterial (oxygenated) blood into the periportal sinusoids directly outside the portal tract connective tissue

27

Chronic Hepatitis

Ground Glass Inclusions
Lymphocytes and other inflammatory cells cross limiting plate

28

Space of Disse

Type III Collagen
Discontinuous Array

29

Least oxygenated hepatocytes

Right around the central vein
They die quickly because they receive the least-oxygenated blood

30

Lipofuscin Pigment

Phagolysosomes with "Wear & Tear" cell debris
Brown Pigment Junk

Appears in Heart, Liver, and Adrenal. Myocytes particularly.
See it first in the hepatocytes surrounding central veins