Flashcards in 1 - Anatomy & Histology of the Liver Deck (73)
Loading flashcards...
1
Normal Liver Mass
1500g
Largest organ
2
Normal Portal Pressure
5 - 10 mm Hg
Low pressure
3
Hepatocytes - Do they all do the same thing?
No!!!!
They have functional heterogeneity
4
Liver's borders
Right 5th rib
Left 6th rib
Right 9th rib
Feel it below the 9th rib and it's HUGE!!!!!!
5
Contents of the portal vein
Collection of venous blood from spleen, splenic vein, SMA, IMA
6
Portal Hypertension
Obstruction to portal vein flow causing pressure to increase above 10mm Hg
7
Post-Hepatic Hypertension
Rarest kind of portal HTN
Congenital webs of the IVC
8
Intra-Hepatic Hypertension
Most common type of portal HTN
Cirrhosis
Other types of pathology
9
Pre-Hepatic Hypertension
Thrombosis blocking entry to the portal vein
10
How many lobes?
2!
11
Components of the liver
2 Lobes
Glisson's Capsule (smooth! IT IS SMOOTH!!)
Falciform Ligament
12
Real divisions of the liver
8 Segments
4 on the left, 4 on the right
Each has its own vascular and biliary pedacle
13
Two sources of blood for the liver
Celiac Trunk > Hepatic Artery > Left & Right Lobes
Splenic Vein + IMA + SMA > Portal Vein
14
Biliary Tree
Bile conducted from ducts inside into common hepatic duct which meets with cystic duct to join the GI tract
15
Lobule
One functional unit of hepatocytes.
Central vein in the center
Arterial flow at the periphery
No connective tissue divisions between lobules the way pigs do!!!
16
Central veins
Marked by venous endothelium
17
Portal tracts
Collagen tracts that carry 3 tubes:
Bile duct
Artery
Vein
Can fibrose in pathways leading to other portal tracts when inflammation fucks that shit up
18
Blood path through a lobule
Portal tracts at periphery
Contents flow through sinudoids in the periportal regions
Undergo hella changes
Enter central veins to go back to the heart.
19
Bile Cannaliculi
Collect bile, interanastomose and form the canal of herring, which drains into the individual bile ducts that drain into the hilum and the common bile duct.
20
Where do the progenitor (stem) cells in the liver live?
The Canal of Herring
21
Description of Lobule
Radiating Cords
Nicely organized
Once Cell Thick (so nicely bathed)
22
Central Veins
Anastomose into Hepatic Veins (R & L)
Exit to IVC
23
Portal Tract on Histo
Nothing but collagen, fibroblasts and triad of structures
Inflammatory
24
Bile Duct
Tube of cuboidal epithelium
25
Limiting Plate
The hepatocytes at the edge of the Portal Tract
Chronic Hepatitis - Lymphocytes and inflammatory cells can infiltrate this structure and cause fibrosis
26
Mixing of Portal Venous and Hepatic Arterial Blood
Hepatic artery branches give off small twigs which empty arterial (oxygenated) blood into the periportal sinusoids directly outside the portal tract connective tissue
27
Chronic Hepatitis
Ground Glass Inclusions
Lymphocytes and other inflammatory cells cross limiting plate
28
Space of Disse
Type III Collagen
Discontinuous Array
29
Least oxygenated hepatocytes
Right around the central vein
They die quickly because they receive the least-oxygenated blood
30
