Flashcards in 1 - Anatomy & Histology of the Liver Deck (73)
Normal Liver Mass
Normal Portal Pressure
5 - 10 mm Hg
Hepatocytes - Do they all do the same thing?
They have functional heterogeneity
Right 5th rib
Left 6th rib
Right 9th rib
Feel it below the 9th rib and it's HUGE!!!!!!
Contents of the portal vein
Collection of venous blood from spleen, splenic vein, SMA, IMA
Obstruction to portal vein flow causing pressure to increase above 10mm Hg
Rarest kind of portal HTN
Congenital webs of the IVC
Most common type of portal HTN
Other types of pathology
Thrombosis blocking entry to the portal vein
How many lobes?
Components of the liver
Glisson's Capsule (smooth! IT IS SMOOTH!!)
Real divisions of the liver
4 on the left, 4 on the right
Each has its own vascular and biliary pedacle
Two sources of blood for the liver
Celiac Trunk > Hepatic Artery > Left & Right Lobes
Splenic Vein + IMA + SMA > Portal Vein
Bile conducted from ducts inside into common hepatic duct which meets with cystic duct to join the GI tract
One functional unit of hepatocytes.
Central vein in the center
Arterial flow at the periphery
No connective tissue divisions between lobules the way pigs do!!!
Marked by venous endothelium
Collagen tracts that carry 3 tubes:
Can fibrose in pathways leading to other portal tracts when inflammation fucks that shit up
Blood path through a lobule
Portal tracts at periphery
Contents flow through sinudoids in the periportal regions
Undergo hella changes
Enter central veins to go back to the heart.
Collect bile, interanastomose and form the canal of herring, which drains into the individual bile ducts that drain into the hilum and the common bile duct.
Where do the progenitor (stem) cells in the liver live?
The Canal of Herring
Description of Lobule
Once Cell Thick (so nicely bathed)
Anastomose into Hepatic Veins (R & L)
Exit to IVC
Portal Tract on Histo
Nothing but collagen, fibroblasts and triad of structures
Tube of cuboidal epithelium
The hepatocytes at the edge of the Portal Tract
Chronic Hepatitis - Lymphocytes and inflammatory cells can infiltrate this structure and cause fibrosis
Mixing of Portal Venous and Hepatic Arterial Blood
Hepatic artery branches give off small twigs which empty arterial (oxygenated) blood into the periportal sinusoids directly outside the portal tract connective tissue
Ground Glass Inclusions
Lymphocytes and other inflammatory cells cross limiting plate
Space of Disse
Type III Collagen
Least oxygenated hepatocytes
Right around the central vein
They die quickly because they receive the least-oxygenated blood