12 - The National Strategy on the Prevention of HBV, HCV andHCC Flashcards Preview

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Flashcards in 12 - The National Strategy on the Prevention of HBV, HCV andHCC Deck (18)
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1

How many people worldwide are living with viral hepatitis?

1 in 12

2

HBV and HCV cause what percentage of cirrhosis worldwide?

57%

3

HBV and HCV cause what percentage of HCC worldwide?

78%

4

What is the leading infectious cause of death in the USA?

Viral hepatitis

5

How much money per year is spent on liver disease?

$5 - 10 billion

6

Goals for attacking this shit

Increase proportion aware of their HBV status to 66%
Increase proportion aware of their HCV status to 66%
Reduce new HCV infections by 25%
Eliminate mother-to-child HBV transmisison

7

Prevention strategies

Immunization
Screening
Behavioral Counseling
Chemoprevention

8

Levels of disease prevention

Primary:
Prevents disease from occurring
Vaccination

Secondary:
Catch early, halt progression
Screening for cancers

Tertiary:
Prevent deterioration
Eliminating allergens from asthma patients

9

HBV Vaccine

Introduced in 1982
Safe & >90% effective
Recommended for newborns of HBV-infected mothers
Universally for infants in the US since 1991
Adolescents
High risk groups (IVDU, dialysis, etc)
Anyone with chronic liver disease

10

HBV Screening

HBsAG
Recommended for those at high risk

11

HBV Chemoprevention

Post-exposure Prophylaxis
Hepatitis B Immune Globulin (HBIG) AND HBV Vaccine

12

Hepatocellular Carcinoma

5th most common cancer worldwide
3rd most common cause of cancer death worldwide
Super closely linked to HBV
INCREASING prevalence worldwide

13

HCC Prevention Guidelines

Ultrasound every 6 months
Blood Test: Alpha Fetoprotein (AFP)
Glycoprotein elevated in patients with HCC
Not good for screening
Good for following course

14

HCC Screening

Actually prevented HCC-related mortality!!!!

15

HCC Screening Test

We aren't using it nearly enough

16

Toxins related to HCC

Aflatoxin (mycotoxin contaminating corn, soybeans, peanuts)
Contaminated drinking water (pond shit)

17

HCC - Chemoprevention

Antiviral Treatment (HBV & HCV)

18

Increased Coffee Consumption

Protects against HCC