1. Cytokine Messenger System Flashcards
(25 cards)
Differentiates pluripotent stem cells into lymphoid progenitors
IL-7 secreted by bone marrow and thymic stromal cells
induces an anti-viral state
Type I IFN
alpha from leukocytes
beta from fibroblasts
degrades mRNA to inhibit protein synthesis
Type I IFN
endogenous pyrogens (3)
IL-1
IL-6
TNF-alpha
alternative macrophages induced by
IL-4 and IL-13
Regulatory cytokines
TGF-Beta
IL-10 (from Macrophages, DC, Tregs)
IL-2, IL-4, IL-5, IFN-gamma, TGF-beta are all secreted by
T cells
Survival, proliferation, and differentiation of effector and regulatory T cells
IL-2
Induces B cell isotype switching to IgE
IL-4
Activates Eosinophils
IL-5
Activates macrophages
IFN-gamma
inhibits T cell activation; differentiation of regulatory T cells
TGF-beta
IFN-gamma and IL-12 will induce mature naive T cells to become
Th1 (through the transcription factor T-bet)
assists in defense against IC pathogens
IL-4 will induce mature naive T cells to become
Th2 (through the transcription factor GATA-3)
assists in defense of parasites
TGF-beta, IL-6, and IL-23 will induce mature naive T cells to become
Th17 (through the tf RORgammaT)
assists in defense against EC pathogens
Cytokine that stimulates the expression of Class II HLA and CD80
IFN-Gamma
induces B cell isotype switching to IgA
TGF-beta, APRIL, BAFF
classically activated macrophages secrete
IL-1, IL-12, IL-23 to induce inflammation
Barrier function is mediated by which subclass of Th cells
Th17 cells
increases barrier function of tissue cells
IL-22
secreted by Th17 cells, induces epithelial tissues to secrete anti-microbial peptides
IL-17
leprosy presenting with organisms at low to undetectable levels will result in a _____ t cell response
Th1 response –> macrophages
which may lead to the formation of granulomas
leprosy presenting with florid growth in macrophages will induce a _____ t cell response
Th2 response –> hypergammaglobulinemia
low or absent t cell responsiveness
in patients with SCID, ______ cell function is always impaired
T cell function is always impaired
