1. Cytokine Messenger System Flashcards Preview

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Flashcards in 1. Cytokine Messenger System Deck (25)
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1

Differentiates pluripotent stem cells into lymphoid progenitors

IL-7 secreted by bone marrow and thymic stromal cells

2

induces an anti-viral state

Type I IFN
alpha from leukocytes
beta from fibroblasts

3

degrades mRNA to inhibit protein synthesis

Type I IFN

4

endogenous pyrogens (3)

IL-1
IL-6
TNF-alpha

5

alternative macrophages induced by

IL-4 and IL-13

6

Regulatory cytokines

TGF-Beta
IL-10 (from Macrophages, DC, Tregs)

7

IL-2, IL-4, IL-5, IFN-gamma, TGF-beta are all secreted by

T cells

8

Survival, proliferation, and differentiation of effector and regulatory T cells

IL-2

9

Induces B cell isotype switching to IgE

IL-4

10

Activates Eosinophils

IL-5

11

Activates macrophages

IFN-gamma

12

inhibits T cell activation; differentiation of regulatory T cells

TGF-beta

13

IFN-gamma and IL-12 will induce mature naive T cells to become

Th1 (through the transcription factor T-bet)
assists in defense against IC pathogens

14

IL-4 will induce mature naive T cells to become

Th2 (through the transcription factor GATA-3)
assists in defense of parasites

15

TGF-beta, IL-6, and IL-23 will induce mature naive T cells to become

Th17 (through the tf RORgammaT)
assists in defense against EC pathogens

16

Cytokine that stimulates the expression of Class II HLA and CD80

IFN-Gamma

17

induces B cell isotype switching to IgA

TGF-beta, APRIL, BAFF

18

classically activated macrophages secrete

IL-1, IL-12, IL-23 to induce inflammation

19

Barrier function is mediated by which subclass of Th cells

Th17 cells

20

increases barrier function of tissue cells

IL-22

21

secreted by Th17 cells, induces epithelial tissues to secrete anti-microbial peptides

IL-17

22

leprosy presenting with organisms at low to undetectable levels will result in a _____ t cell response

Th1 response --> macrophages
which may lead to the formation of granulomas

23

leprosy presenting with florid growth in macrophages will induce a _____ t cell response

Th2 response --> hypergammaglobulinemia
low or absent t cell responsiveness

24

in patients with SCID, ______ cell function is always impaired

T cell function is always impaired

25

IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21 all share

a common gamma chain
related to SCID somehow idk