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Flashcards in Mechanisms of Hypersensitivity Deck (11)
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1

Type 1 hypersensitivity mediated by

IgE, Mast cell derived mediators
"immediate"

2

mast cell mediators

preformed (granules) - histamine, serotonin, heparin, serine proteases
newly formed lipid mediators (eicosanoids)
prostaglandin D2, Leukotrienes

3

major contributor to tissue damage

eosiniphils induced by FCER1

4

Leukotriene function

increase capillary permeability and mucus production
slower effect, similar to histamine
much more powerful and longer-acting

5

IL-4 function

Th2 growth factor
IgE isotype switching
Increases expression of Vcam

6

IL-13 function

airway eosinophilia
mucus gland hyperplasia
airway fibrosis and remodeling

7

IL-5 function

regulator of eosinophil production and survival

8

TNF function

recruitment and activaiton of inflammatory cells
altered function and growth fo airway smooth muscles

9

only cells that contain histamine

basophils and mast cells

10

preformed mediators of mast cells include

histamine
heparin
trypstase
release quickly (5 minutes)

11

generated mediators of mast cells include

arachidonic acid
leukotriene D4
prostaglandin D2
released in 5-30 minutes
after 30 --> IL-4, TNF-alpha