Ab Mediated Immune Responses: Humoral Immunity Flashcards Preview

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Flashcards in Ab Mediated Immune Responses: Humoral Immunity Deck (9)
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1

resting mature naive B cells express 6 things

BCR - IgM, IgD, Igalpha and Igbeta
Co-BCR - CD19, CD81, CR22 (CD21)
HLA-class II
CD40
CD45R(A)
CD20

2

In the secondary lymphoid tissue, B cells recieve what from follicular dendritic cells?

Survival signals - without these naive b cells would die within weeks

3

B cells enter LN throug h

HEV

4

in order to provide first signal to B cells, Ag must

crosslink 2 or more BCR
activates Igalpha and Igbeta ITAMs

5

Igalpha and Igbeta associate with BCR and serve what purpose?

signaling, contain ITAM domains
interaction with BCR causes src kinases to phosphorylate these ITAMs --> Syk recruited --> gets phosphorylated --> PLCgamma - DAG - Ras/Rac GTP

6

BCR activation induces what transcription factors

Myc
NFAT
NF-KB
AP-1

7

second signal for b cell activation

CR2 (CD21) binds bound C3d on Ag and enhances BCR signaling from Igalpha and Igbeta
apparently TLRs can do the same thing

8

After Ag recognition, B cells migrate

to the edge of the follicular zone to interact with helper T cells

9

Th cells can provide secondary signal to B cells through

T cell CD40L binding CD40 receptor on B cell for T dependent Ag