4. Cell Mediated Immunity Flashcards Preview

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Flashcards in 4. Cell Mediated Immunity Deck (16)
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1

Mature Naive T cells express what surface markers (6)

CD4 or CD 8
CD28
HLA class I
TCR complex (with CD3)
LFA-1 and VLA-4 adhesion molecules
Chemokine receptors

2

Only cell that can activate naive T cells

DC

3

T cells enter LN through what structure?

High endothelial venules into the cortex

4

T cell activation (full) leads to the production of what transcription factors

NFAT
NF-KB
AP-1

5

CD80 (also known as _____) binds to what

B7-1/B7-2
binds CD28 of CD4+ T cells

6

After Ag recognition from DCs, T cells increase their adhesion through

inducing a high affinity state of integrins and clustering them

7

Without costimulation of with B7 (CD80) to its receptor _____, T cells will

B7:CD28
T cells will become anergic/not respond

8

CTLs may require costimulation by _____ when being presented Ag from DCs

CD4+ expression of cytokines

9

T cell cytokines (5)

IL-2 - T cell survival/prolif/diff signal
IL-4 - IgE class switching
IL-5 - activate eosinophils
IFN-gamma - activate macrophages
TGF-beta - inhibit T cell activation/diff Treg cells

10

effector T cells differ from naive resting T cells in their ability to

respond to their specific Ag without costimulation from CD80 to their CD28 receptor

11

T cell memory survival signals

IL-7
IL-15
reactivated by self MHC+ self peptide

12

Tregs express this molecule to bind CD28 and shut down IL-2 production

CTLA-4

13

CTLA-4 major function

negative regulation of immune responses; self-tolerance: binds B7-1 B7-2 receptors

14

PD1 major function

Negative regulation of T cells
expressed on T cells, B cells, myeloid cells

15

after Ag has arrived in the LN, it takes approximately how many days for effector cells to migrate to the periphery?

5 days

16

t cell transcription factors are activated within _____ and include _____

minutes - C-Fos
hours - C-Myc