Tolerance and Autoimmunity Flashcards Preview

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Flashcards in Tolerance and Autoimmunity Deck (16)
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1

Central tolerance occurs in

the generative lymphoid organs
recognition of self Ag will lead to apoptosis, b cell receptor editing or development of regulatory T cells

2

Peripheral tolerance occurs in

peripheral tissues
recognition of self Ag in the peripheral tissue results in Anergy, apoptosis, or suppression (by T regs)

3

AIRE protein

Autoimmune regulator protein
stimulates expression of peripheral "tissue-restricted" self Ag in the thymus
involved in the negative selection T cells undergo

4

FoxP3 upregulates

CD25 in regulatory T cells

5

Peripheral T cell tolerance is mediated by this receptor

CTLA-4 - preferentially binds B7 (from APCs) in the absence of infection/inflammation
Its activation leads to T cell anergy

6

Fates of a B cell that recognizes self (3)

1) receptor editing
2) deletion
3) Anergy

7

Autoimmunity is chronic due to

amplification loops - small numbers of self-Ag lymphocytes increase in number after response, gets worse in subsequent bouts with autoimmunity

8

Autoimmunity is persistent due to

epitope spreading - response against one self-Ag causes damage that releases other Ag - T lymphocytes may be reactive to these Ag

9

SLE

defective apoptosis leads to increase nucleic acid Ag
ends up producing auto-Ab

10

RA

inflammation of the synovium
Th17/Th1 cytokine release sustains the inflammatory response
Auto Ab production against Rheumatoid factor (Fc protion of IgG)
leads to the destruction of cartilage and bone

11

Inhibit TNF-alpha

Infliximab (remicade)
adalimumab (Humira)
Golimumab (Simponi)
Etanercept (Enbrel)
Certolizumab pegol (cimzia)

12

Blocking CD25 with monoclonal Ab would serve to

decrease T cell autocrine response to IL-2

13

Blocking CTLA-4 with monoclonal Ab would serve to

prevent B7 binding CD28, promote anergy

14

Blocking adhesion molecules/chemokine receptors with monoclonal Ab would serve to

prevent infiltration of T cells into the periphery

15

Monoclonal Ab specific for anti- CD20 would

target mature naive B cells for deletion

16

IPEX means

no Treg cells in periphery
due to FoxP3 mutations