1-G Skin Histology Flashcards

1
Q

Define the two types of skina and where they are found.

A

Thick skin is found on palms and soles of feet, areas that need greatest protection from abrasion; thin skin is found everywhere else on the body

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2
Q

What type of connective tissue is the papillary dermis

A

loose connective tissue

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3
Q

What type of connective tissue is reticular layer of the dermis

A

type I collagen densse irregular connective tissue; also includes vasculature, innervation, hair follicles and glands.

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4
Q

Reticular layer of dermis is organized in by ____ ____ (important in scarring)

A

Langer’s Lines

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5
Q

What types of tissue are found in hypodermis?

A

adipose and loose connective tissue

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6
Q

What are the 5 layers of the epidermis

A

basale, spinosum, granulosum, lucidum, coneum

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7
Q

Name important characteristics of the 5 layers.

A

Basale (basement membrane, spot desmosomes and hemidesmosomes); Spinosum (many spot desmosomes); Granulosusm (granules of keratohyalin and dense homogenous deposit granules of for water barrier); Lucidum (dead cells); Corneum (being sloughed off)

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8
Q

What is the function of Langerhans cells

A

they are the immune cells of the skin (easily damaged by UV)

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9
Q

What is the function fo Merkel cells

A

located in the basal layers of epidermis and contain neurosecretory granules and work with sensory neruons

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10
Q

What embryonic tissue are melanocytes derived from

A

neural crest

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11
Q

Describe the structure of hair follicles

A

interaction between dermis and epidermis cause the epidermis to invaginate into the dermis, at the base of mature follicle there is atuft of vascular loose connectibe tissue called the dermal papilla that stimulates the production of hair (hair made of karatinocytes and melanocytes); can go through cycles of growth and dormancy

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12
Q

What serves as the duct for sebaceous glands

A

hair follicle

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13
Q

Integrate the functional relationship between hair follicles, sebaceous glands and arrector pili muscles

A

Arrector pilli muscles can cause secretion of sebaceous glands into the hair follicles that are used as a duct

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14
Q

Explain how sebaceous gland produce and secrete sebum

A

cells fill with oily product until their death and then are excreted by holocrine secretion

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15
Q

Name the two types of sweat glands

A

eccrine (most common for thermoregulation and intiated by sympathetic ) Apocrine (secret into hair follicles in the axilla, nipple and genital area producing a viscous sweat)

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16
Q

What is the motor innervation of the skin

A

smooth muscle of the arrector pili muscle and blood vessels is innervated by sympathetic nervous system which is necessary for thermoregulation

17
Q

Describe the types of unencapsulated

A

free nerve endings detect pain and temperature; Merkel endings are touch receptors that contact Merkel cells

18
Q

Describe the types of the encapsulated receptors

A

mesissner’s corpuscles (light touch receptors nestled in dermal papilla); pacinian corpuscles are vibration receptors found in the dermis or hypodermis

19
Q

Contrast the embryonic origins of the epidermis and dermis

A

dermis (mesoderm) epidermis (ectoderm)

20
Q

What is hypodermis also know as

A

subcutaneous tissue or superficial fascia

21
Q

What is another name for investing fascia

A

describes the outermost layer of fascia surrounding skeletal muscle- epimysium

22
Q

What are the two major types of skin cancer?

A

basal cell carcinoma (stem cells grow out of control, clear border) and melanoma (uncontrolled growth of melanocytes due to over exposure to sun, can invade deep tissues and metastisize)

23
Q

How does psoriasis affect cell proliferation within the epidermis

A

immune system alters the growth rate of epidermis leading to 4 day transit and redness due to growing tissue

24
Q

Describe two conditions that lead to altered malanocyte function

A

albinism (decreased ability to synthesize melanin- lack of tyrosinase) and addison’s disease (over expression of MSH, increasing skin pigmentation.