1: Haemopoiesis Flashcards Preview

Haematology Week 3 2018/19 > 1: Haemopoiesis > Flashcards

Flashcards in 1: Haemopoiesis Deck (25)
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1

What is haemopoiesis?

Production of blood cells

2

What is the average life span of a red blood cell?

120 days

3

What is the average life span of a platelet?

7 - 10 days

4

What is the average life span of a neutrophil?

7 - 8 hours

5

If the bone marrow is suppressed, which blood cells become deficient first?

Why?

Neutrophils

Shortest life span

6

Which type of blood cell is polyploid?

Megakaryocytes

7

What is unique about the cell division of haemopoietic stem cells?

Capacity for self renewal

One of the daughter cells with be a HSC identical to its mother cell

So they can divide forever

8

What is meant by myeloid?

Re: malignancy - a bone marrow malignancy

Re: lineage - non-lymphoid i.e granulocytes and lymphoid cells

9

Which germ layer do HSCs originate from?

Mesoderm

10

By which week of life does bone marrow haemopoiesis start?

Week 16

11

In children, which areas of bone marrow undergo haemopoiesis?

All of the bone marrow

12

In adults, which areas of bone marrow undergo haemopoiesis?

Axial skeleton

Pelvis

Proximal long bones only

13

From which site is a bone marrow biopsy carried out in

a) adults

b) children?

a) PSIS

b) Anterior tibia

14

Apart from haemopoietic cells, what other cells exist in the bone marrow?

Fat cells

Osteoblasts

Osteoclasts

Fibroblasts

15

Through which structures in bone marrow are newly produced blood cells released?

Sinusoids

16

Blood enters the bone marrow via ___.

Blood cells enter the plasma, then the plasma re-enters the circulation via ___.

capillaries

sinusoids

17

What is special about the basement membrane of bone marrow sinusoids?

Discontinuous

Allows blood cells to enters the plasma

18

What are the gaps in the basement membrane of a bone marrow sinusoid called?

Fenestrations

19

Bone marrow sinusoids have adventitial cells - what are the function of these cells?

Contain smooth muscle - dilate and constrict to increase/decrease blood flow

20

What colour is

a) active

b) fatty, inactive bone marrow?

a) Red

b) Yellow

21

What is the myeloid:erythroid ratio?

Ratio of neutrophils (and precursors) to red blood cell precursors

22

The myeloid:erythroid ratio usually favours (myeloid / erythroid) cells.

myeloid cells

i.e more neutrophils than RBCs

23

In which situation is the myeloid:erythroid ratio reversed?

Blood loss

Haemolysis

i.e situations demanding erythropoiesis

24

What is the only way to figure out the type of lymphocyte you're looking at on a blood film?

Immunophenotyping

looking at specific antigens expressed on their cell membrane

25

How does immunophenotyping work?

Each lymphocyte has specific antigens on their cell membrane

Add specific antibodies with fluorescent tag attached and shine light on it

Target cells will light up