What is haemopoiesis?
Production of blood cells
What is the average life span of a red blood cell?
What is the average life span of a platelet?
7 - 10 days
What is the average life span of a neutrophil?
7 - 8 hours
If the bone marrow is suppressed, which blood cells become deficient first?
Shortest life span
Which type of blood cell is polyploid?
What is unique about the cell division of haemopoietic stem cells?
Capacity for self renewal
One of the daughter cells with be a HSC identical to its mother cell
So they can divide forever
What is meant by myeloid?
Re: malignancy - a bone marrow malignancy
Re: lineage - non-lymphoid i.e granulocytes and lymphoid cells
Which germ layer do HSCs originate from?
By which week of life does bone marrow haemopoiesis start?
In children, which areas of bone marrow undergo haemopoiesis?
All of the bone marrow
In adults, which areas of bone marrow undergo haemopoiesis?
Proximal long bones only
From which site is a bone marrow biopsy carried out in
b) Anterior tibia
Apart from haemopoietic cells, what other cells exist in the bone marrow?
Through which structures in bone marrow are newly produced blood cells released?
Blood enters the bone marrow via ___.
Blood cells enter the plasma, then the plasma re-enters the circulation via ___.
What is special about the basement membrane of bone marrow sinusoids?
Allows blood cells to enters the plasma
What are the gaps in the basement membrane of a bone marrow sinusoid called?
Bone marrow sinusoids have adventitial cells - what are the function of these cells?
Contain smooth muscle - dilate and constrict to increase/decrease blood flow
What colour is
b) fatty, inactive bone marrow?
What is the myeloid:erythroid ratio?
Ratio of neutrophils (and precursors) to red blood cell precursors
The myeloid:erythroid ratio usually favours (myeloid / erythroid) cells.
i.e more neutrophils than RBCs
In which situation is the myeloid:erythroid ratio reversed?
i.e situations demanding erythropoiesis
What is the only way to figure out the type of lymphocyte you're looking at on a blood film?
looking at specific antigens expressed on their cell membrane
How does immunophenotyping work?
Each lymphocyte has specific antigens on their cell membrane
Add specific antibodies with fluorescent tag attached and shine light on it
Target cells will light up