7: Cytotoxic drugs (chemotherapy) Flashcards Preview

Haematology Week 3 2018/19 > 7: Cytotoxic drugs (chemotherapy) > Flashcards

Flashcards in 7: Cytotoxic drugs (chemotherapy) Deck (16)
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1

What are cytotoxic drugs?

Drugs which kill cells

i.e chemotherapy

2

Which types of haematological malignancy can chemotherapy be used to treat?

AML

ALL

Lymphoma

Myeloproliferative disease

Myeloma

3

Which process, undergone by all cells, do most cytotoxic drugs target?

Cell cycle

4

Which DMARD is used to treat some cancers and interferes with folate metabolism?

Methotrexate

5

What is a specific side effect of anthracycline chemotherapy?

Cardiomyopathy

6

What are immediate side effects of chemotherapy?

Bone marrow failure

GI symptoms due to damage re: gut mucosa

Hair loss

7

Is alopecia caused by chemotherapy permanent or temporary?

Temporary

8

What is a side effect specific to vinca alkaloid chemotherapy drugs?

Neuropathy

9

What is a side effect specific to platinum chemotherapy drugs?

Nephropathy

10

Chemotherapy drugs are often used in ___.

combination

11

Chemotherapy can be intensified to the point that you're essentially wiping out a patient's blood cell population.

How do you overcome this problem?

Stem cell transplant

12

A stem cell transplant can come from the patient themselves (___) or a matched donor (____).

patient themselves - autologous

matchde donor - allogenic

13

Apart from replacing blood cells lost to chemotherapy, how does a stem cell transplant affect the growth of cancer?

Graft vs disease effect

Antibodies produced towards malignant cells

14

Which chromosomal abnormality is chronic myeloid leukaemia associated with?

Philadelphia chromosome

15

The Phildelphia chromosome mutation is associated with which malignancy?

Chronic myeloid leukaemia

16

Which drug is highly effective in treating chronic myeloid leukaemia?

Imatinib

tyrosine kinase inhibitor