4: Investigation of lymphadenopathy Flashcards Preview

Haematology Week 3 2018/19 > 4: Investigation of lymphadenopathy > Flashcards

Flashcards in 4: Investigation of lymphadenopathy Deck (28)
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1

What is lymphadenopathy?

Enlarged lymph nodes

2

Is lymphadenopathy the same as lymphoma?

No

3

What causes lymphadenopathy?

Infection

Malignancy (lymphoma or metastatic disease)

Connective tissue diseases

4

What are some B symptoms which accompany lymphoma?

Night sweats

Weight loss

Fever

5

What are some symptoms specific to Hodgkins lymphoma?

Itch without a rash

Alcohol-induced pain

6

Which investigation is carried out to exclude lymphoma?

Lymph node biopsy

7

What are the patterns of lymphadenopathy seen in

a) bacterial

b) viral infection?

a) Regional enlargement

b) Generalised enlargement

8

Which virus causes glandular fever?

EBV

9

Glandular fever causes ___ lymphadenopathy.

Why?

Generalised lymphadenopathy

EBV (viral) infection

10

Malignancy causes ___ lymphadenopathy.

regional

but can also refer to weird places

11

What is a specific lymphadenopathy seen in some apical lung cancers?

Virchow's node (supraclavicular) enlargement

12

Viral lymphadenopathy is an inflammatory process - true or false?

False

13

Bacterial lymphadenopathy is an inflammatory process - true or false?

True

14

What are some properties of malignancy lymphadenopathy?

Non-tender

Hard

Irregular

Tethered - invading local tissue

15

How is lymphadenopathy investigated?

Whole node biopsy

16

Can lymphoma be diagnosed by imaging?

No

17

What is meant by reactive lymphadenopathy?

Enlarged lymph nodes in response to infection

18

What lymph node structures enlarge in response to infection, malignancy or connective tissue disease?

Follicles

because the B cells are activated

19

Immunohistochemistry is similar to immunophenotyping - what is the difference?

Immunophenotyping - fluorescent tags

Immunohistochemistry - chemical stains

20

Non-Hodgkins lymphoma cells are ____ positive.

CD20+

21

Which specific cells are seen in Hodgkins lymphoma?

Reed-Sternberg cells

presence of these is the criteria for calling it Hodgkins as opposed to Non-Hodgkins

22

Which drug can be given to treat Non-Hodgkins lymphoma?

Rituximab

B cell inhibitor

23

Non-Hodgkins lymphoma is ___ positive.

CD20+

24

Which genetic analysis can be used to identify the specific type of lymphoma?

FISH

25

How does rituximab work?

Which type of lymphoma is it used to treat?

Binds to CD20 and induces apoptosis

Non-Hodgkins lymphoma

26

Which grade of lymphoma is curable using chemotherapy?

High grade lymphoma only

27

What is a specific, highly aggressive Non-Hodgkins lymphoma?

Burkitt's lymphoma

28

Which type of lymphoma doesn't respond to chemotherapy but is high grade?

Mantle cell lymphoma