2: Structure and function of lymph nodes and spleen Flashcards Preview

Haematology Week 3 2018/19 > 2: Structure and function of lymph nodes and spleen > Flashcards

Flashcards in 2: Structure and function of lymph nodes and spleen Deck (28)
Loading flashcards...
1

Where do

a) B cells

b) T cells

mature?

a) Bone marrow

b) Thymus

2

What are the two central lymphoid tissues?

Bone marrow

Thymus

3

What are some peripheral lymphoid tissues?

Lymph nodes

Spleen

Tonsils

4

A fraction of the circulation is filtered as ___.

lymph

5

Lymphoid tissues contain ___ cells.

immune cells

i.e white blood cells

6

The lymphatic system stops fluid from accumulating in the tissues.

What symptom do you have when this doesn't happen?

Lymphoedema

7

What is the dilated part of the thoracic duct which carries lymph from the intestines and lower limbs?

Cisterna chyli

8

Describe the location of the

a) superficial

b) deep

inguinal nodes?

a) Superficial inguinal nodes - directly inferior to inguinal ligament, run horizontally

b) Deep inguinal nodes - run vertically along the medial aspect of the femoral vein

9

Before draining at the thoracic duct or left lymphatic duct, where does lymph go?

Lymph nodes

10

In which specific part of a lymph node are B cells found?

Primary follicles

11

Which part of a lymph node follicle becomes activated?

Germinal centre

12

What do B cells differentiate into?

Where in a lymph node are they found?

Plasma cells

Medulla

13

What disease processes cause lymphadenopathy?

Inflammation (local or systemic)

Infection

Malignancy

14

By which structures do cancers often metastasise?

Lymph nodes

causing lymphadenopathy

15

What is the differential diagnosis for a patient with generalised lymphadenopathy?

Malignancy - specifically haematological cancers e.g lymphoma

Rheumatic disease e,g RA, SLE

Viral infection

16

What granulomatous condition causes bilateral hilar lymphadenopathy and erythema nodosum in many patients?

Sarcoidosis

i.e buzzwords buzzwords buzzwords

17

Where is the spleen found?

LUQ

18

Why is splenic rupture, especially when enlarged, a medical emergency?

Massive haemorrhage

19

Just like bone marrow, the spleen contains ___ which accept blood cells and release them into the circulation.

sinusoids

20

What is the function of the spleen?

Lymphoid organ

so filters blood and immune surveillance

21

What is the function of the

a) red pulp

b) white pulp of the spleen?

a) Highly vascular, carries blood to white pulp

b) Immune surveillance

22

What are the symptoms of splenomegaly?

LUQ dragging sensation

Pain on eating

23

What blood change occurs in hypersplenism?

Fall in 1+ blood components

24

What anatomical change occurs in hypersplenism?

Splenomegaly

25

What are some causes of splenomegaly?

Infection

Cardiovascular disease (e.g heart failure)

Blood malignancies

Rheumatic diseases

26

What is the most common reason for hyposplenism?

Splenectomy

Your spleen function is reduced if you do not have a spleen

27

What can be seen morphologically in hyposplenism?

Howell-Jolly bodies

Solid purple dots within normal-looking RBCs

28

Which GI condition is associated with splenic atrophy?

Coeliac disease