a) B cells
b) T cells
a) Bone marrow
What are the two central lymphoid tissues?
What are some peripheral lymphoid tissues?
A fraction of the circulation is filtered as ___.
Lymphoid tissues contain ___ cells.
i.e white blood cells
The lymphatic system stops fluid from accumulating in the tissues.
What symptom do you have when this doesn't happen?
What is the dilated part of the thoracic duct which carries lymph from the intestines and lower limbs?
Describe the location of the
a) Superficial inguinal nodes - directly inferior to inguinal ligament, run horizontally
b) Deep inguinal nodes - run vertically along the medial aspect of the femoral vein
Before draining at the thoracic duct or left lymphatic duct, where does lymph go?
In which specific part of a lymph node are B cells found?
Which part of a lymph node follicle becomes activated?
What do B cells differentiate into?
Where in a lymph node are they found?
What disease processes cause lymphadenopathy?
Inflammation (local or systemic)
By which structures do cancers often metastasise?
What is the differential diagnosis for a patient with generalised lymphadenopathy?
Malignancy - specifically haematological cancers e.g lymphoma
Rheumatic disease e,g RA, SLE
What granulomatous condition causes bilateral hilar lymphadenopathy and erythema nodosum in many patients?
i.e buzzwords buzzwords buzzwords
Where is the spleen found?
Why is splenic rupture, especially when enlarged, a medical emergency?
Just like bone marrow, the spleen contains ___ which accept blood cells and release them into the circulation.
What is the function of the spleen?
so filters blood and immune surveillance
What is the function of the
a) red pulp
b) white pulp of the spleen?
a) Highly vascular, carries blood to white pulp
b) Immune surveillance
What are the symptoms of splenomegaly?
LUQ dragging sensation
Pain on eating
What blood change occurs in hypersplenism?
Fall in 1+ blood components
What anatomical change occurs in hypersplenism?
What are some causes of splenomegaly?
Cardiovascular disease (e.g heart failure)
What is the most common reason for hyposplenism?
Your spleen function is reduced if you do not have a spleen
What can be seen morphologically in hyposplenism?
Solid purple dots within normal-looking RBCs
Which GI condition is associated with splenic atrophy?