A blood film contains macrovalocytes and hypersegmented neutrophils.
Which type of anaemia is these buzzwords referring to?
What is the cause?
Megaloblastic anaemia (a type of macrocytic anaemia)
Vitamin B12 / Folate deficiency
Which autoimmune disease can cause B12 / Folate malabsorption?
What are two blood film buzzwords for B12 / Folate deficiency?
What is a blood film finding specific to acute myeloid leukaemia?
A patient's blood film contains Auer rods.
Which haematological malignancy is this referring to?
Acute myeloid leukaemia (AML)
Remember CML has its own buzzwords: Philadelphia chromosome (22) mutation, BCR-ABL1 positive, treated with imatinib
What does a monocyte look like under the microscope?
In which situations would you give a patient
a) iron tablets
b) iron injections?
a) Mild iron deficiency anaemia
b) Severe iron deficiency anaemia
How do you treat autoimmune haemolytic anaemia?
How do you treat Waldenstrom's (IgM) disease?
Which anticoagulant drugs target Factor Xa?
i.e all the novel anticoagulants with -xa- in their name
Which type of blood cells express CD20 antigens?
Which type of blood cells express CD30 antigens?
Which drug targets CD20 and can therefore be used to target B cell lymphomas?
Which drug targets BCR-ABL1 tyrosine kinase?
Which haematological malignancy is this enzyme associated with?
Which drug targets Factors II, VII, IX and X?
Which disease is JAK2 mutation associated with?
Polycythaemia rubra vera
Which drug potentiates the action of antithrombin?
Which types of this drug potentiate antithrombin's action against
b) factor Xa?
a) Unfractionated heparin
b) LMWH e.g dalteparin
Which drug inhibits platelet activation by inactivating cycloxygenase enzymes?
Which drug inhibits primary haemostasis by antagonising ADP?
Which NOAC directly inhibits thrombin?
Bence Jones proteins (light chains found in a urine sample) indicates which haematological malignancy?
Which drugs tend to cause a prolonged
a) PT / INR
Which disease causes a drop in platelets and fibrinogen, plus prolonged clotting times?
Disseminated intravascular coagulation (DIC)
Treat with platelet transfusions and fresh frozen plasma
Treat underlying cause
Which disease are you testing for with a JAK2 gene analysis?
Polycythaemia rubra vera
i.e primary polycythaemia
What is the purpose of a Coombs test?
To differentiate between an autoimmune and non-autoimmune cause of haemolytic anaemia
(Autoimmune HA is Coombs positive, other causes e.g Sickle cell are Coombs negative)
What disease is associated with a raised serum caeruloplasmin?
Immunophenotyping is used to differentiate between different kinds of ___.
What is a Kleihauer test used to detect?
Name two tests which can be used to detect thalassaemia.
Osmotic fragility analysis
because this is a disease affecting globin chains
Name a cause of single factor deficiency.