1: Hyperthyroidism, hypothyroidism and thyroiditis Flashcards Preview

Endocrine Week 3 2017/18 > 1: Hyperthyroidism, hypothyroidism and thyroiditis > Flashcards

Flashcards in 1: Hyperthyroidism, hypothyroidism and thyroiditis Deck (77)
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1

Thyroid disease can be ___ or ___.

primary , secondary

2

What is a goitre?

Lump in the thyroid gland

3

Primary thyroid disease is usually ___.

autoimmune

4

Secondary thyroid disease is usually caused by disease of which glands?

Hypothalamus

Pituitary gland

5

Which hormone is released from the anterior pituitary gland and affects the function of the thyroid gland?

Thyroid stimulating hormone (TSH)

also known as thyrotropin

6

TSH is also known as ___.

Thyrotropin

7

What are the two hormones produced by the thyroid gland?

T3

T4

"thyroxines"

8

99% of T3 and T4 is bound to what?

Transport proteins

Thyroxine binding globulin

Albumin

Pre-albumin

9

Which hormone, produced by the hypothalamus, triggers the anterior pituitary's production of TSH?

Thyrotropin releasing hormone (TRH)

10

The hypothalamic-pituitary-thyroid axis is controlled by ___ feedback.

negative feedback

11

What happen to the levels of free T3/T4 and TSH in

a) primary hypothyroidism

b) primary hyperthyroidism?

a) Primary hypothyroidism - free T3/4 LOW, TSH HIGH

b) Free T3/4 HIGH, TSH LOW

12

In secondary hypothyroidism, is TSH raised?

No

13

Secondary hyperthyroidism is very rare. What are the levels of T3/4 and TSH?

Everything is high

14

What is hypothyroidism?

Insufficient secretion of thyroid hormones

15

What is severe hypothyroidism also known as?

Myxoedema

16

What is a rare sign of Graves disease, which itself causes hyperthyroidism?

Pretibial myxoedema

17

Hypothyroidism is very (common / uncommon).

common

18

Reduced intake of what can cause hypothyroidism?

Iodine

19

Hypothyroidism is categorised by the presence or absence of a...

goitre

20

What is an autoimmune cause of hypothyroidism which presents with a goitre?

Hashimoto's thyroiditis

21

What occurs in Hashimoto's thyroiditis?

Auotimmune destruction of thyroid gland

Reduced thyroid hormone secretion

22

Hashiomoto's thyroiditis is more common in (men / women).

women

As with all autoimmune disease

23

What antibodies are seen in Hashimoto's disease?

Thyroid peroxidase antibodies (TPO)

24

What is seen histologically in Hashimoto's disease?

T cell infiltration

25

Why are the symptoms of thyroid disease so diverse?

Systemic impact of hormones

26

What is seen in the hair and skin of someone with hypothyroidism?

Coarse, sparse hair

Expressionless, puffy face

Pale, cold skin

Vitiligo

Hypercarotenaemia (orange skin)

27

People with hypothyroidism will complain of being very (hot / cold).

cold

28

What is seen in the ankles of people with hypothyroidism?

Pitting oedema

29

What are some cardiovascular complications of hypothyroidism?

Bradycardia

Cardiac dilatation

Effusions

Hyperlipidaemia (inc. xanthelasma)

30

People with hypothyroidism have a REDUCED appetite - what happens to their weight?

They gain weight anyway