1 - Intro Flashcards
(42 cards)
6 basic hallmarks of cancer
Self sufficient growth, no response to anti growth signals, evasion of apoptosis , limitless replicate potential, sustained angiogenesis, ability to invade and metastasize
First four hallmarks of cancer
Self sufficient cell growth, no response to anti growth signals, evasion of apoptosis, limitless replication potiental
Last two hallmarks of cancer
Sustained angiogenesis, ability to invade and metastasize
Etiology of cancer
Mutations, genetic, environmental, infectious, dietary, hormonal , chronic inflammation
How many heritable cancers
Over 200
German shepherd heritable cancer
RCND - kidney and skin
RCND has a mutation in
Folliculin gene
RCND is what dominant
Autosomal
Bernie mountain dog predispose
Histiocytic cancer
Boxer predisposed to
Lymphoma and mast cell tumor
Golden retriever disposition
Lymphoma
German shepherd dispo
Hemangiosarcoma
Scottish terrier and sheepdog disposed to
Traditional cell carcinoma of the bladder
30% death in USA
Smoking inn humans
Dogs in smoking household what is the risk
3.4 increased risk for lymphoma or nasal carcinoma
Cats in smoke house hold risk
2.4 increase lymphoma or oral
Pesticides can cause
Lymphoma in human and dogs or transitional cell carcinoma of bladder in dogs
Dogs in urban environment
Lymphoma, tonsil lab squamous cell carcinoma,nasal carcinoma
Dogs near water sites
Lymphoma
Humans in sunlight
Cutaneous melanoma
Dogs in sunlight
Dermal hemangiosarcoma and cutaneous squamous cell carcinoma
Cats in sunlight
Carcinoma of nasal planum, ear pinnae and eyelids
High exposure of EM field
Childhood leukemia, canine lymphoma
Being exposed to radiation
Hematologist cancer, sarcomas