1 - Intro Flashcards

(42 cards)

1
Q

6 basic hallmarks of cancer

A

Self sufficient growth, no response to anti growth signals, evasion of apoptosis , limitless replicate potential, sustained angiogenesis, ability to invade and metastasize

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2
Q

First four hallmarks of cancer

A

Self sufficient cell growth, no response to anti growth signals, evasion of apoptosis, limitless replication potiental

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3
Q

Last two hallmarks of cancer

A

Sustained angiogenesis, ability to invade and metastasize

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4
Q

Etiology of cancer

A

Mutations, genetic, environmental, infectious, dietary, hormonal , chronic inflammation

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5
Q

How many heritable cancers

A

Over 200

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6
Q

German shepherd heritable cancer

A

RCND - kidney and skin

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7
Q

RCND has a mutation in

A

Folliculin gene

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8
Q

RCND is what dominant

A

Autosomal

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9
Q

Bernie mountain dog predispose

A

Histiocytic cancer

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10
Q

Boxer predisposed to

A

Lymphoma and mast cell tumor

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11
Q

Golden retriever disposition

A

Lymphoma

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12
Q

German shepherd dispo

A

Hemangiosarcoma

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13
Q

Scottish terrier and sheepdog disposed to

A

Traditional cell carcinoma of the bladder

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14
Q

30% death in USA

A

Smoking inn humans

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15
Q

Dogs in smoking household what is the risk

A

3.4 increased risk for lymphoma or nasal carcinoma

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16
Q

Cats in smoke house hold risk

A

2.4 increase lymphoma or oral

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17
Q

Pesticides can cause

A

Lymphoma in human and dogs or transitional cell carcinoma of bladder in dogs

18
Q

Dogs in urban environment

A

Lymphoma, tonsil lab squamous cell carcinoma,nasal carcinoma

19
Q

Dogs near water sites

20
Q

Humans in sunlight

A

Cutaneous melanoma

21
Q

Dogs in sunlight

A

Dermal hemangiosarcoma and cutaneous squamous cell carcinoma

22
Q

Cats in sunlight

A

Carcinoma of nasal planum, ear pinnae and eyelids

23
Q

High exposure of EM field

A

Childhood leukemia, canine lymphoma

24
Q

Being exposed to radiation

A

Hematologist cancer, sarcomas

25
Asbestos exposure
Mesothelioma
26
FeLV risk
70 fold increase risk for lymphoma
27
FeLV co infection risk with
FIV
28
Spirochete Lupi risk
Esophageal fibrosarcoma
29
Schistosomiasis risk
Bladder cancer
30
Papillomavirus
Cutaneous warts
31
Obesity in dogs linked to
Bladder cancer and mammary cancer
32
Obese human risk
Breast, pancreatic, colon cancer
33
When should u spay to prevent mammary cancer
Before 6 months of age
34
Intact dogs are at risk for
Testicular cancer
35
Neutered dogs are at increased risk of risk of
Prostatic cancer
36
Trauma/chronic inflammation in cat can lead to increase risk of
Feline ocular sarcoma, FIS, IBD
37
Treatment options for cancer
Surgery, radiation , chemo, targeted agents, immunotherapy, clinical trials
38
Definitive therapy
Therapy with intent to cure or provide prolonged
39
Palliative therapy
Go to when cancer is too advanced or incurable
40
Median Survival Time
50% of patients are alive at a certain period of time and 50% have died
41
Disease Free Interval
From emission to relapse?
42
Cure
Cancer free of 8 years?