9 - Radiation Flashcards
(59 cards)
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Absorption of on ejoule of radiation energy per one kilogram of matter
Vast majority of tumors treated with radiation will die due to
Necrosis
The four R
Repair, repopulation, redistribution, reoxygenating
Which tumor can u see response rlly quickly
Lymphoma
The most important R
Repair
Repair can happen in both
Tumor and normal cells
What % of normal cells are recovered due to compensatory proliferation
50 - 60
Redistribution has to do with
Cell cycles
What cell phase is cell most sensitive to radiation
G2/M
What two blocks of cell cycle
G1 S and G2 M
What % of tumors have hypoxia
50
Oxygenated cells are more sensitive to
Radiation
Acute hypoxia
Reopening of closed capillaries
Chronic hypoxia
Oxygenated cells die allowing oxygen to diffuse to new areas
Definitive radiation
Long term tumor control, daily treatments, small daily dose
Palliative radiation
Shorter survival times, weekly treatments, high daily dose
Acute side effects of radiation related to
Stem cell damage
Acute side effects starts
During the third week of treatment
Acute side effects last
2 -3 weeks after treatment
Acute Sid effects are related to
Total dose
Special acute effects
Tear glands, lung tissue, brain tissue
Topical treatment to acute side effects
Clean radiation site, ointments, vitamin E oil
Oral treatment for acute side effects
NSAID , Gabapentin, tramadol, opioids
Ointments used for acute side effects
Proteque and silvadene