11 - Chemo

Question 1

Indications for chemotherapy

Answer 1

Most effective single therapy for some malignancies, delay or prevent metastatic tumors after surgery, palliative for non resectable tumors, shrink large tumor

Question 2

What type of tumor is chemotherapy most effectie single therapy for some malignancy

Answer 2

Lymphoma

Question 3

Most cells are in what phase

Answer 3

G0 resting

Question 4

Normal cells constantly dividing

Answer 4

Bone marrow precursors, GI crypt cels, hair cells

Question 5

Chemo wil kill

Answer 5

Rapidly dividing cells

Question 6

Is chemo targeted

Answer 6

No

Question 7

Chemo side effects

Answer 7

Bone marrow supression, alopecia, and GI upset

Question 8

Cytotoxic chemo

Answer 8

Directly killing diving tumor cells

Question 9

Cytotoxic therapy

Answer 9

Giving the highest dose of chemo as you can

Question 10

In between doses of cytotoxic chemotherapy

Answer 10

Tumor cells grow between doses

Question 11

Metronomic Chemo

Answer 11

Lose dose chemotherapy

Question 12

Does metronomic chemotherapy kill tumor cells

Answer 12

No

Question 13

Metronomic chemotherapy works by

Answer 13

Inhibiting angiogenesis and activating immune system

Question 14

Goal of metronomic chemotherapy

Answer 14

Tumor stabilization

Question 15

Chemo dosing

Answer 15

Body surface area

Question 16

With weight to BSA conversion charts always

Answer 16

Round down

Question 17

Neutrophils are apart of teh

Answer 17

innate immune system

Question 18

What is the first line of defense against infection

Answer 18

Neutrophils

Question 19

What cell has the shortest half life of all white blood cells

Answer 19

Neutrophils

Question 20

Neutropenia

Answer 20

most common dose liming toxicity of chemotherapy

Question 21

Chemo effects on neutrophil

Answer 21

Stops neutrophils in bone marrow from going to the peripheral blood

Question 22

Which pool of neutrophils is effected by chemo

Answer 22

Proliferating pool

Question 23

Prior to chemo evaluation

Answer 23

HCT, neutrophils, PLT

Question 24

Want neutrophils to be

Answer 24

Grater than 2500

Question 25

Platelets want to be

Answer 25

Greater than 150,000

Question 26

Danger zone of neutrophils

Answer 26

Less than 1,000

Question 27

If neutrophils are less than 1000

Answer 27

Oral antibiotics , sepsis, ab, decrease dose

Question 28

Usual chronic side effect of chemo

Answer 28

Thrombocytopenia

Question 29

Most common anemia

Answer 29

Non regenerative anemia - anemia of inflammatory disease

Question 30

Chemo affects hair in

Answer 30

Anagen phase

Question 31

What types of cells are in teh crypts of GI

Answer 31

Rapidly dividing

Question 32

GI side effects occur how may days post chemo

Answer 32

3 - 5 days

Question 33

GI signs of chemo

Answer 33

Vomiting, diarrhea, anorexia a

Question 34

MDR1

Answer 34

Drug efflux pump

Question 35

Mutation in MDR1 s/e

Answer 35

Increased intracellular drug concentrations - increase side effects and death

Question 36

What examples of drugs that can cause local tissue reaction if given SQ

Answer 36

Vincristine and doxorubicin

Question 37

In event of possible extravasating

Answer 37

SLAP

Question 38

NonDNA binding vesicants

Answer 38

Vincristine and vinblastine

Question 39

Vincristine and vinblastine cause

Answer 39

Burn , swelling, edema, and ulcer

Question 40

DNA binding vesicants

Answer 40

Doxorubicin

Question 41

Doxorubicin causes

Answer 41

Progressive tissue destruction

Question 42

Administer with doxorubicin

Answer 42

Dexrazoxane

Question 43

Drug residues may present in urine and feces up to how many hours after administration

Answer 43

72 hours