Flashcards in 10/6/12 Deck (35):
Which autoimmune disease is associated w/ myocardial fibrosis?
On what arm of what chromosome is the tumor supressor gene BRCA-1 located?
Where is the VHL gene located?
Where is the APC gene located?
What chromosome is the frataxin gene located on?
On which chromosome is the DPC (pancreatic cancer) gene located?
What do heaves indicate on a cardiac exam?
Where would the heave of right ventricular be felt?
left parasternal area
Describe the heave of LV hypertrophy?
sustained apical heave
Palsy of upward gaze, dissociation of light an d accomodation, and failure of convergence indicate compression of the _______.
What kind of childhood brain tumor would present w/ headache, nausea, vomiting, and papilledema along w/ cerebellar signs such as ataxia, dysarthria, nystagmus, and intention tremor?
astrocytoma of the cerebellum
What is the relationship between pressure, flow, and resistance?
What is TPR in terms of CO and MAP?
TPR = MAP/CO
What is the most common means of drug-resistance transfer, esp. among Gram(-) bacilli?
F+ to F- conjugation (plasmid transfer)
What is the means by which S. pneumoniae likely gain PBP mutations?
What is the means by whic S. aureus is thought to gain methicillin resistance and P. aeruginosa imipenem resistance?
What are 3 important bacteria capable of natural transformation?
S. pneumoniae, H. influenzae, and Neisseria spp.
What is the most common bacterial STD in America?
What cytokines, released by the Th1 cell, activate the cytotoxic T-cell?
IL-2, IFN-γ, and TNF-β
What kind of hypersensitivity rxn is PID?
What cytokines, released by Th2 cells, inhibit Th1 cells?
IL-4 and IL-10
What cytokine, released by Th1 cells, inhibit Th2 cells?
Defects in what enzyme could cause hypospadias and poor development of male genitalia?
Drug of choice in uncomplicated Lyme disease?
doxycycline or amoxicillin
What is the drug of choice in complicated lyme disease?
The only non-competitive alpha-blocker used clinically is? What would be its uses?
phenoxybenzamine; malignant htn or pheochromocytoma
What is PRAZOCIN?
What is phentolamine?
What is the main difference in the activities of epinephrine and norepinephrine?
NE does not stimulate β-2 (That's why epinephrine is used for anaphylaxis!)
What is the main clinical difference between Hashimoto's thyroiditis and subacute granulomatous thyroiditis?
DeQuervain's is tender and Hashimoto's is not.
Which oral antifungal is typically used against dermatophytes, as it accumulates in the stratum corneum?
Which antifungal is like a topical form of amphotericin B?
Which azole crosses the BBB?
Which antyifungal is used for invasive aspergillosis?