10/6/12 Flashcards Preview

Kaplan Qbank > 10/6/12 > Flashcards

Flashcards in 10/6/12 Deck (35):
0

Which autoimmune disease is associated w/ myocardial fibrosis?

systemic sclerosis

1

On what arm of what chromosome is the tumor supressor gene BRCA-1 located?

17q

2

Where is the VHL gene located?

3p

3

Where is the APC gene located?

5q

4

What chromosome is the frataxin gene located on?

9

5

On which chromosome is the DPC (pancreatic cancer) gene located?

18

6

What do heaves indicate on a cardiac exam?

ventricular hypertrophy

7

Where would the heave of right ventricular be felt?

left parasternal area

8

Describe the heave of LV hypertrophy?

sustained apical heave

9

Palsy of upward gaze, dissociation of light an d accomodation, and failure of convergence indicate compression of the _______.

tectum

10

What kind of childhood brain tumor would present w/ headache, nausea, vomiting, and papilledema along w/ cerebellar signs such as ataxia, dysarthria, nystagmus, and intention tremor?

astrocytoma of the cerebellum

11

What is the relationship between pressure, flow, and resistance?

P=QR

12

What is TPR in terms of CO and MAP?

TPR = MAP/CO

13

What is the most common means of drug-resistance transfer, esp. among Gram(-) bacilli?

F+ to F- conjugation (plasmid transfer)

14

What is the means by which S. pneumoniae likely gain PBP mutations?

transformation

15

What is the means by whic S. aureus is thought to gain methicillin resistance and P. aeruginosa imipenem resistance?

specialized transduction

16

What are 3 important bacteria capable of natural transformation?

S. pneumoniae, H. influenzae, and Neisseria spp.

17

What is the most common bacterial STD in America?

Chlamydia trachomatis

18

What cytokines, released by the Th1 cell, activate the cytotoxic T-cell?

IL-2, IFN-γ, and TNF-β

19

What kind of hypersensitivity rxn is PID?

type IV

20

What cytokines, released by Th2 cells, inhibit Th1 cells?

IL-4 and IL-10

21

What cytokine, released by Th1 cells, inhibit Th2 cells?

IFNγ

22

Defects in what enzyme could cause hypospadias and poor development of male genitalia?

α-reductase

23

Drug of choice in uncomplicated Lyme disease?

doxycycline or amoxicillin

24

What is the drug of choice in complicated lyme disease?

IV ceftriaxone

25

The only non-competitive alpha-blocker used clinically is? What would be its uses?

phenoxybenzamine; malignant htn or pheochromocytoma

26

What is PRAZOCIN?

competitive alpha-blocker

27

What is phentolamine?

non-selective alpha-blocker

28

What is the main difference in the activities of epinephrine and norepinephrine?

NE does not stimulate β-2 (That's why epinephrine is used for anaphylaxis!)

29

What is the main clinical difference between Hashimoto's thyroiditis and subacute granulomatous thyroiditis?

DeQuervain's is tender and Hashimoto's is not.

30

Which oral antifungal is typically used against dermatophytes, as it accumulates in the stratum corneum?

Griseofulvin

31

Which antifungal is like a topical form of amphotericin B?

Nystatin

32

Which azole crosses the BBB?

fluconazole

33

Which antyifungal is used for invasive aspergillosis?

caspofungin

34

Which antiprotozoan would you use for toxoplasmosis or malaria?

pyrimethamine