10/1/12 Flashcards Preview

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Flashcards in 10/1/12 Deck (18):
1

What is the mech of malathion and other organophosphates?

irreversible inhibition of cholinesterase

2

What other major effect do first generation H1 antagonists have that leads to many of their side effects?

anticholinergic

3

A pt has mydriasis, palpitations, and muscle weakness. Which symptom would indicate that this is d/t botulinum toxin and not atropine?

muscle weakness (nicotinic receptors!)

4

What autoimmune disease is anti-glutamic acid decarboxylase seen in?

DM I

5

What is the mech of acarbose in DM 2 tx?

alpha-glucosidase inhibitor - inhibits pancreatic and intestinal enzymes to slow the absorption of glucose

6

What vitamin should be supplemented during phototherapy for neonatal jaundice, as it is also degraded by sunlight?

Riboflavin

7

Where does unconjugated bilirubin accumulate to cause neurological problems in kernicterus?

basal ganglia

8

What are the only cells capable of killing infected RBCs?

NK

9

What is the most specific cell surface marker for NK cells?

CD-56

10

Multiple sclerosis is classified as a _______ hypersensitivity disease.

type IV

11

What hepatits virus has a special propensity for infecting pregnant women?

HEV

12

What viral family does HEV belong to?

HepEviridae

12

What testicular cancer consists of nests of cells w/ conspicuous nucleoli and clear cytoplasm - nests surrounded by thin, fibrous septae?

seminoma

13

Seminomas are classically express what marker?

placental alkaline phosphatase (PLAP)

14

What two types of cells make up a seminoma?

neoplastic cells and lymphocytes

15

What is the most common testicular neoplasm in men ages 15-35?

seminoma

16

What kind of testicular cancer could cause feminization or masculinization?

Leydig or Sertoli cell tumors

17

What kind of reaction is inflamation at the site of a protein innoculation 24-48 hrs later?

Arthus reaction - type III hypersensitivity