11. Diabetes Insipidus Flashcards

(26 cards)

1
Q

(DI)

Ätiologie (2)

A
  • centralis
  • renalis
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2
Q

(DI)

-centralis: Pathophysiologie

A

↓ ADH-Ausschüttung aus der Hypophyse

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3
Q

(DI)

-renalis: Pathophysiologie

A

↓ ADH-Sensivität der Nieren

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4
Q

(DI)

Differenzialdiagnosen (2)

A
  • DM
  • Hyperkalzämie
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5
Q

(DI)

Leitsymptom

A

Polyurie-Polydipsie-Syndrom

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6
Q

(DI)

Labordiagnostik (2)

A

Blut- und Urin-

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7
Q

(DI)

Laborbefunde in Blut (2)

A
  • Hyperosmolalität
  • Hypernatriämie
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8
Q

(DI)

Laborbefund in Urin

A

Hypoosmolalität

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9
Q

(DI)

Diagnosesicherung

A

Durstversuch

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10
Q

(DI)

Durstversuch: Dauer

A

bis 17h

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11
Q

(DI)

Durstversuch: Auswertung (3)

A

Urinosmolalität

  • ↑ : unauffällig
  • ↔︎ : primäre Polydipsie o. unvollständiger DI centralis
  • ↓ : DI
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12
Q

(DI)

Unterscheidung

A

Desmopressin-Test

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13
Q

(DI)

Desmopressin-Test

A

ADH-Gabe nach Durstversuch

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14
Q

(DI)

Desmopressin-Test: Auswertung

A

Urinosmolalität

  • ↓ dann ↑ > 50%: DI centralis
  • ↓ dann ↑ ≤ 50%: DI renalis
  • ↔︎ dann ↑ > 9%: unvollständige DI centralis
  • ↔︎ dann ↑ ≤ 9%: primäre Polydipsie
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15
Q

(DI)

Bildgebung der Wahl

A

cMRT

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16
Q

(DI)

cMRT: Indikation

A

bei DI centralis

17
Q

(DI)

Therapie der Wahl

A

medikamentöse

18
Q

(DI)

medikamentöse Therapie der Wahl

A
  • ADH-Analogon
  • Thiazide
19
Q

(DI)

ADH-Analogon der Wahl

20
Q

(DI)

Desmopressin: Applikation

A

i.n. dann p.o.

21
Q

(DI)

Thiazide: Wirkung

A

paradoxe Wirkung: Steigerung der Natriumexkretion

22
Q

(DI)

Therapie: Komplikationen (2)

A
  • Hyponatriämie
  • Wasserintoxikation
23
Q

(DI)

-centralis: Testbefunde (2)

A

Urinosmolalität

  • ↓ nach Durstversuch
  • ↑ > 50% nach ADH-Gabe
24
Q

(DI)

unvollständiger DI centralis: Testbefunde (2)

A

Urinosmolalität

  • ↔︎ nach Durstversuch
  • ↑ > 9% nach ADH-Gabe
25
(DI) -renalis: Testbefunde (2)
Urinosmolalität - ↓ nach Durstversuch - ↑ ≤ 50 % nach ADH-Gabe
26
(DI) primäre Polydipsie: Testbefunde (2)
Urinosmolalität - ↔︎ nach Durstversuch - ↑ ≤ 9% nach ADH-Gabe