10. myelodysplastische Syndrome Flashcards by Ian Paglione

Q

(MDS)

Definition

A

klonale Proliferation hämatopoetischer Stammzellen

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Q

(MDS)

Pathophysiologie

A

dysplastische Zellen mit Apoptoseneigung

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Q

(MDS)

Ätiologie (Häufigkeit)

A

90% primäre
10% sekundäre

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Q

(MDS)

Epidemiologie: mittleres Erkrankungsalter

A

75 J.

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Q

(MDS)

Differenzialdiagnosen (4)

A

andere Anämie-Formen
andere hämatologische Neoplasien
reaktive KM-Veränderungen
toxischer KM-Schaden

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Q

(MDS)

Leitsymptome (2)

A

asymptomatisch
durch Zytopenien

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Q

(MDS)

Befund

A

Hepatosplenomegalie

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Q

(MDS)

Leitbefund im Blutbild

A

Zytopenien

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Q

(MDS)

häufigste Zytopenie

A

normo- bis makrozytäre Anämie

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Q

(MDS)

andere Zytopenien (2)

A

Leukozytopenie
Thrombozytopenie

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Q

(MDS)

Diagnosesicherung: Goldstandard

A

Knochenmarkaspirat und -biopsie

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Q

(MDS)

Befund im Knochenmarkaspirat

A

Dysplasie

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Q

(MDS)

mögliche dysplastische Befunde (2)

A

ggf. ↑ Blastenzahl
ggf. Ringsideroblasten

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Q

(MDS)

bioptischer Befund

A

Hyperzellularität

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Q

(MDS)

Diagnostik: Zusammenfassung

A

“Penie peripherer und Zellreichtum zentral”

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Q

(MDS)

Therapieplanung (2)

Study These Flashcards

A

supportive-
ggf. MDS-spezifische

Q

(MDS)

MDS-spezifische Therapie: Möglichkeiten

Study These Flashcards

A

Arzneimittel
allogene Stammzelltransplantation

Q

(MDS)

einzige kurative Therapieoption

Study These Flashcards

A

allogene Stammzelltransplantation