9. chronische Leukämien Flashcards by Ian Paglione

Q

(CML)

Ätiologie

A

Philadelphia-Translokation

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Q

(CML)

Philadelphia-Translokation

A

t(9;22)

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Q

(CML)

Pathophysiologie

A

t(9;22) → BCR-ABL-Fusionsgen

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Q

(CML)

Häufigkeitsgipfel

A

60 Ljz.

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Q

(CML)

Leitsymptome (2)

A

B-Symptomatik
chronische Fatigue

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Q

(CML)

Leitbefund

A

hochgradige Splenomegalie ohne Lymphadenopathie

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Q

(CML)

Laborbefunde (3)

A

extreme Leukozytose
Anämie
Thrombozytopenie

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Q

(CML)

Diagnosesicherung

A

Knochenmarkaspirat und -Biopsie

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Q

(CML)

Knochenmarkaspirat: Befund

A

zytogenetischer Nachweis des Philadelphia-Chromosoms

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Q

(CML)

Therapie der Wahl:

A

TKI

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Q

(CML)

TKI

A

Tyrosinkinase-Inhibitoren

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Q

(CML)

TKI: Wirfstoffe

A

“tinib”

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Q

(CML)

Therapie der 2. Wahl

A

allogene Stammzelltransplantation

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Q

(CLL)

Definition

A

niedrig-malignes B-Zell-Lymphom

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Q

(CLL)

Epidemiologie

A

häufigste Leukämieform

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Q

(CLL)

mittleres Erkrankungsalter

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A

70 J.

Q

(CLL)

Leitsymptome (2)

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A

B-Symptomatik
chronische Pruritus/Urtikaria

Q

(CLL)

Befund

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A

Splenomegalie mit indolenter Lymphadenopathie

Q

(CLL)

Labordiagnostik (3)

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A

Blutbild
Blutausstrich
Immunphänotypisierung

Q

(CLL)

Blutbild: Befunde (3)

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A

Leukozytose mit ↑ Lymphozytenanteil
Anämie
Thrombozytopenie

Q

(CLL)

Blutausstrich: Befund

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A

Grumprecht-Kernschatten

Q

(CLL)

Immunphänotypisierung: Befund

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A

Nachweis von B-CLL-Immunphänotyp

Q

(CLL)

B-CLL-Immunphänotyp (3)

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A

CD19, CD20, CD23

Q

(CLL)

Therapieentscheidung

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A

nach Binet-Klassifikation

(CLL) Binet-Klassifikation: Stadien

A, B, C

(CLL) Therapie: Indikation im Stadium A

nur in Einzelfällen

(CLL) Therapie: Indikation im Stadium B

symptomatische Patienten

(CLL) Therapie: Indikation im Stadium C

alle Patienten

(CLL) Therapiemöglichkeiten (3)

- Purinanaloga - Alkylazien - AK