Drugs Acting on the RAAS

Question 1

HTN

Answer 1

increase in the blood pressure such that the systolic pressure is >140mm/H

Question 2

Untreated HTN can lead

Answer 2

heart disease, kidney disease, stroke, etc.

Question 3

3 Regulatory Systems for BP:

Answer 3

Sympathetic nervous system
RAAS
Kidneys

Question 4

Drugs for HTN:

Answer 4

Diuretics
Beta Adrenergic Blockers
Calcium Channel Blockers
Inhibitors of the RAAS System

Question 5

Kidneys regulate

Answer 5

blood pressure, blood volume, and fluid and electrolyte balance through the renin-angiotensin-aldosterone (RAAS) system

Question 6

The RAAS raises blood pressure through

Answer 6

vasoconstriction and water and sodium retention

Question 7

ACE inhibitors block the production of

Answer 7

Angiotensin II; promote diuresis, improve circulation and improve cardiac function

Question 8

ACE inhibitors used to treat

Answer 8

HTN, heart failure, diabetic nephropathy, MI, and prevention of cardiovascular events

Question 9

ACE inhibitors in African Americans can cause

Answer 9

angioedema; not for pregnant; for diabetics with HTN

Question 10

Types of ACE inhibitors

Answer 10

PRIL
captopril
enalapril
lisinopril 
ramipril
benazepril

Question 11

Side Effects (for all ACEI)

Answer 11

DRY COUGH
first dose hypotension
HYPERkalemia
ANgioedema

Question 12

Angiotensin II Receptor Blockers (ARBS)

Answer 12

SARTAN

blocks angiotension 2 and aldosterone; causing vasodilation and diuresis

Question 13

losartan (Cozaar)
olmesartan (Benicar)
valsartan (Diovan)

Answer 13

ARBS
effects: orthostatic hypotension
hyperkalemia
angioedema

Question 14

Aldosterone Antagonist (diuretic)

Answer 14

For HTN and heart failure

Eplerenone

Question 15

Eplerenone side effects

Answer 15

hyperkalemia avoid salt subs

Question 16

Direct Renin Inhibitor

Answer 16

stops antiotensinogen into angiotensin I, thereby suppressing the entire RAAS;
HTN

aliskiren

Question 17

aliskiren

Answer 17

renin inhibitor; less likely to cause hyperkalemia angioedema or cough