non surgical treatment of lung cancer

Question 1

chemotherapy side effect

Answer 1

marrow suppression, nausea and vomiting, fatigue, hair loss, nail changes, neuropathy, increased stroke risk, neutropenic sepsis

Question 2

radiotherapy side effect

Answer 2

acute- lethargy, oesophagitis, SOB due to pneumonitis, long term- pulmonary fibrosis, oesophageal stricture, cardiac problems

Question 3

chemotherapy outcomes

Answer 3

median survival of less than 12 months with chemo alone but palliative

Question 4

ECOG (eastern cooperative group) measurement

Answer 4

performance status measurement 0 asymtomatic and well, 5 is dead

Question 5

adjuvant

Answer 5

after definitive procedure

Question 6

neoadjuvant

Answer 6

before definitive procedure

Question 7

adjuvant therapy examples

Answer 7

radiotherapy and chemotherapy

Question 8

neoadjuvant therapy examples

Answer 8

chemotherapy in stage 3 sometimes but overall not used much

Question 9

plan for radiotherapy

Answer 9

planning for 2 weeks, assessing fitness and discussing plan, 55Gy in 20 fractions - mon to fri for 4 weeks

Question 10

plan for radiotherapy

Answer 10

planning for 2 weeks, assessing fitness and discussing plan, must be fit in lung function, 55Gy in 20 fractions - mon to fri for 4 weeks

Question 11

plan for chemotherapy

Answer 11

cycle lasts for 21 days, start radiotherapy with cycle 2 of chemo

Question 12

outcome of concurrent chemoRT

Answer 12

survival rate better than RT alone, 2 year survival rate is around 27%. increases toxicity tho because chemo is systemic. more nausea, GI upset, infection

Question 13

plan for concurrent chemoRT

Answer 13

cycle lasts for 21 days, start radiotherapy with cycle 2 of chemo

Question 14

outcome of concurrent chemoRT

Answer 14

survival rate better than RT alone, 2 year survival rate is around 27%. increases toxicity tho because chemo is systemic. more nausea, GI upset, infection

Question 15

stereotactic ablative radiotherapy SABR

Answer 15

high dose on a small area peripherally

Question 16

plan for chemotherapy

Answer 16

given as a doublet regime, two drugs given as Iv infusion every 3 weeks, quality of life measured, usually 4 cycles.

Question 17

palliative radiotherapy

Answer 17

management of symptoms eg bone metastasis, cord compression, haemoptysis

Question 18

treatment of SCLC limited disease

Answer 18

CRT curative treatment and combination of drugs

Question 19

treatment of SCLC extensive disease

Answer 19

4 cycles of combination chemotherapy, consolidation thoracic radiotherapy, RT if can’t do chemo

Question 20

immunotherapy side effects

Answer 20

colitis, pneumonitis, dermatitis, endocrinopathies