Aileen Q-Fever

Question 1

What type of zoonosis is Q-Fever?

Answer 1

Endemic

Question 2

What si the name of the pathogen of Q-Fever?

Answer 2

Coxiella burnetti

Question 3

What is the taxonomy of Coxiella?

Answer 3

Family: coxielllacae
Genus: coxiella
Species: Coxiella burnetti

Question 4

What serovars or clades does coxiella have?

Answer 4

Serovars: +10

Question 5

What is the morphology of Coxiella?

Answer 5

Morphology: coccobaccilli Phase1: Smooth has a complete O antigen (most common phase) Phase 2: Rough lack terminal O antigen (typically lab found form)

Question 6

What is the Gram-stain of coxiella?

Answer 6

Negative

Question 7

What is the O2 requirements of coxiella?

Answer 7

aerobic

Question 8

Is coxiella motile?

Answer 8

no

Question 9

Does coxiella form spores?

Answer 9

Spore like forms

Question 10

What is the survival rate of coxiella?

Answer 10

Room Temperature: Can survive for up to 10 days outside of a host 4C fridge: can survive up to a month Dust: 120 days Milk: 40 months

Question 11

What is the fatlaity rate of coxiella?

Answer 11

low

Question 12

What is the life cyce of coxiella?

Answer 12

Many different life cycles: 
Ticks
Blood 
Fmoite
Direct contact

Question 13

What is the infection route of coxiella?

Answer 13

Tick: do a bite Contact: aerosolised, direct contact, Person, fomites and ingestion Host Cells: Monocytes and macrophages Recptor: αvβ3 intergrin receptors Endocytosis: actin dependent Autophage: dins with endosome creates a Nacent ccv: RAB5, EEA1, and LCS Lysosome: lysosome binds to form maturing ccv: Lamp1 and Rab7 Mature ccv: pH4.5, RAB1B, RHO-GTPase, CT5D. Reproduction: then the coxiella reproduce

Question 14

What is Q-fever history?

Answer 14

1920: thought to be rickettsia 1925: Hideyo Moguchi described the illness but lost all the samples so it could not be confirmed.
1935: Brisbane: Abbetoir called Q-fever 1938: Cox and Burnett name the illness as coxiella burnetti after outbreak in montane-9mile
1940: Outbreak down wind of a farm: aerosolised infection confirmed

2002: Straw wall in building: 95 cases 2007: 30 peoplpe from straw at a farm dance infected