[LEC] History of Immunoserology — Milestones

Question 1

Jenner (1798)

Answer 1

Smallpox vaccination

Question 2

Haeckel (1862)

Answer 2

Phagocytosis

Question 3

Metchkinoff (1883 -1905)

Answer 3

Cellular immunity through phagocytosis

Question 4

Pasteur (1880 to 1881, 1885)

Answer 4

Attenuated chicken cholera and anthrax vaccine

Therapeutic vaccincation

Rabies vaccine

FATHER of Immunology

Question 5

Von Behring, Kitasata (1890)

Answer 5

Humoral theory of immunity

Question 6

Koch (1891)

Answer 6

Cutaneous (delayed-type) hypersensitivity

Question 7

Emil Roux (1894)

Answer 7

Passive immunization

Question 8

Ehrlich (1900)

Answer 8

Antibody formation theory

Question 9

Portier, Richet (1902)

Answer 9

Immediate-hypersensitivity anaphylaxis

Question 10

Arthus (1903)

Answer 10

Intermediate hypersensitivity

Question 11

Marrack (1938)

Answer 11

Ag-Ab binding

Allograft rejection

Question 12

Salk, Sabin (1949)

Answer 12

Polio Vaccine

Question 13

Reed (1951)

Answer 13

Yellow fever vaccine

Graft vs. Host reaction

Question 14

Burnet (1957)

Answer 14

Clonal section theory

Interferon

Human leukocyte antigens (HLAs)

Question 15

Edelman, Porter (1972)

Answer 15

Identification of Ab molecule

Question 16

Köhler (1975)

Answer 16

First monoclonal Ab

Question 17

Snell (1980)

Answer 17

Genes that control graft rejection

Question 18

Dausset (1980)

Answer 18

Identify surface molecules to decrease graft rejection

Question 19

Benacerraf (1980)

Answer 19

Inheritance of animals to make Ab to defined molecules

Ability to respond to an Ag determining resistance and susceptibility

Genes for T-Cell receptor

Monoclonal Hepa B vaccine

Question 20

Mosmann (1986)

Answer 20

Th1 vs Th2 model of T-helper cell function

Question 21

Murray, Thomas (1990, 1996-1998, 2001)

Answer 21

Kidney and bone marrow transplantation

Toll-like receptors

FOXP3 - gene for directing regulatory T-cell development

Question 22

Frazer (2005)

Answer 22

Human papilloma virus vaccine