[LEC] History of Immunoserology — Milestones Flashcards

1
Q

Jenner (1798)

A

Smallpox vaccination

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2
Q

Haeckel (1862)

A

Phagocytosis

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3
Q

Metchkinoff (1883 -1905)

A

Cellular immunity through phagocytosis

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4
Q

Pasteur (1880 to 1881, 1885)

A

Attenuated chicken cholera and anthrax vaccine

Therapeutic vaccincation

Rabies vaccine

FATHER of Immunology

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5
Q

Von Behring, Kitasata (1890)

A

Humoral theory of immunity

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6
Q

Koch (1891)

A

Cutaneous (delayed-type) hypersensitivity

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7
Q

Emil Roux (1894)

A

Passive immunization

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8
Q

Ehrlich (1900)

A

Antibody formation theory

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9
Q

Portier, Richet (1902)

A

Immediate-hypersensitivity anaphylaxis

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10
Q

Arthus (1903)

A

Intermediate hypersensitivity

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11
Q

Marrack (1938)

A

Ag-Ab binding

Allograft rejection

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12
Q

Salk, Sabin (1949)

A

Polio Vaccine

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13
Q

Reed (1951)

A

Yellow fever vaccine

Graft vs. Host reaction

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14
Q

Burnet (1957)

A

Clonal section theory

Interferon

Human leukocyte antigens (HLAs)

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15
Q

Edelman, Porter (1972)

A

Identification of Ab molecule

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16
Q

Köhler (1975)

A

First monoclonal Ab

17
Q

Snell (1980)

A

Genes that control graft rejection

18
Q

Dausset (1980)

A

Identify surface molecules to decrease graft rejection

19
Q

Benacerraf (1980)

A

Inheritance of animals to make Ab to defined molecules

Ability to respond to an Ag determining resistance and susceptibility

Genes for T-Cell receptor

Monoclonal Hepa B vaccine

20
Q

Mosmann (1986)

A

Th1 vs Th2 model of T-helper cell function

21
Q

Murray, Thomas (1990, 1996-1998, 2001)

A

Kidney and bone marrow transplantation

Toll-like receptors

FOXP3 - gene for directing regulatory T-cell development

22
Q

Frazer (2005)

A

Human papilloma virus vaccine