SURFACE MARKERS on T & B Cells

Question 1

CD2

Answer 1

Thymocytes
T cells
NK cells

—

Involved in T cell activation

Question 2

CD3

Answer 2

Thymocytes
T cells

—

Associated with T cell Ag receptor
T cell receptor transduction

Question 3

CD4

Answer 3

Helper T cells
Monocytes
Macrophages

—

Co-receptor for MHC II
Receptor for HIV

Question 4

CD5

Answer 4

Mature T cells
Thymocytes
B1 subset of B cells

—

Positive or negative modulation of T & B receptor signaling

Question 5

CD8

Answer 5

Thymocyte subsets
Cytotoxic T cells

—

Co receptor for MHC I

Question 6

CD10

Answer 6

B & T cell precursors
Bone marrow — stromal cells

—

Protease; a marke for pre-B common acute lymphocytic Ag (CALLA)
**Marker for immature B cells

Question 7

CD16

Answer 7

Macrophages
NK cells
Neutrophils

—

Low-affinity Fc receptor mediates phagocytosis & ADCC

Question 8

CD19

Answer 8

B cells
follicular dendritic cells

—

Part of B cell co-receptor
Signal transduction molecule that regulates B cell development and activation

Question 9

CD21

Answer 9

B cells
Follicular dendritic cells
Subset of immature thymocytes

—

Receptor for complement component C3d
Part of B cells co-receptor with CD19

Question 10

CD23

Answer 10

B cells
Monocytes
Follicular dendritic cells

—

Regulation of IgE synthesis
Triggers the release of GM-CSF from monocytes

Question 11

CD25

Answer 11

Activated T & B cells
Monocytes

—

Receptor for IL-2

Question 12

CD44

Answer 12

Most leukocytes

—

Adhesion molecule mediating homing to peripheral lymphoid organs

Question 13

CD45R

Answer 13

Different forms on all hematopoietic stem cells

—

Essential in T & B Ag stimulated activation

Question 14

CD56

Answer 14

NK cells, subsets of T cells

—

Not known
** Most unique marker of NK

Question 15

CD94

Answer 15

NK cells
Subsets of T cells

—

Subunit of NKG2-A complex involved in inhibition of NK cell cytotoxicity