SURFACE MARKERS on T & B Cells Flashcards
CD2
Thymocytes
T cells
NK cells
—
Involved in T cell activation
CD3
Thymocytes
T cells
—
Associated with T cell Ag receptor
T cell receptor transduction
CD4
Helper T cells
Monocytes
Macrophages
—
Co-receptor for MHC II
Receptor for HIV
CD5
Mature T cells
Thymocytes
B1 subset of B cells
—
Positive or negative modulation of T & B receptor signaling
CD8
Thymocyte subsets
Cytotoxic T cells
—
Co receptor for MHC I
CD10
B & T cell precursors
Bone marrow — stromal cells
—
Protease; a marke for pre-B common acute lymphocytic Ag (CALLA)
**Marker for immature B cells
CD16
Macrophages
NK cells
Neutrophils
—
Low-affinity Fc receptor mediates phagocytosis & ADCC
CD19
B cells
follicular dendritic cells
—
Part of B cell co-receptor
Signal transduction molecule that regulates B cell development and activation
CD21
B cells
Follicular dendritic cells
Subset of immature thymocytes
—
Receptor for complement component C3d
Part of B cells co-receptor with CD19
CD23
B cells
Monocytes
Follicular dendritic cells
—
Regulation of IgE synthesis
Triggers the release of GM-CSF from monocytes
CD25
Activated T & B cells
Monocytes
—
Receptor for IL-2
CD44
Most leukocytes
—
Adhesion molecule mediating homing to peripheral lymphoid organs
CD45R
Different forms on all hematopoietic stem cells
—
Essential in T & B Ag stimulated activation
CD56
NK cells, subsets of T cells
—
Not known
** Most unique marker of NK
CD94
NK cells
Subsets of T cells
—
Subunit of NKG2-A complex involved in inhibition of NK cell cytotoxicity