SURFACE MARKERS on T & B Cells Flashcards

1
Q

CD2

A

Thymocytes
T cells
NK cells

Involved in T cell activation

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2
Q

CD3

A

Thymocytes
T cells

Associated with T cell Ag receptor
T cell receptor transduction

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3
Q

CD4

A

Helper T cells
Monocytes
Macrophages

Co-receptor for MHC II
Receptor for HIV

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4
Q

CD5

A

Mature T cells
Thymocytes
B1 subset of B cells

Positive or negative modulation of T & B receptor signaling

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5
Q

CD8

A

Thymocyte subsets
Cytotoxic T cells

Co receptor for MHC I

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6
Q

CD10

A

B & T cell precursors
Bone marrow — stromal cells

Protease; a marke for pre-B common acute lymphocytic Ag (CALLA)
**Marker for immature B cells

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7
Q

CD16

A

Macrophages
NK cells
Neutrophils

Low-affinity Fc receptor mediates phagocytosis & ADCC

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8
Q

CD19

A

B cells
follicular dendritic cells

Part of B cell co-receptor
Signal transduction molecule that regulates B cell development and activation

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9
Q

CD21

A

B cells
Follicular dendritic cells
Subset of immature thymocytes

Receptor for complement component C3d
Part of B cells co-receptor with CD19

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10
Q

CD23

A

B cells
Monocytes
Follicular dendritic cells

Regulation of IgE synthesis
Triggers the release of GM-CSF from monocytes

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11
Q

CD25

A

Activated T & B cells
Monocytes

Receptor for IL-2

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12
Q

CD44

A

Most leukocytes

Adhesion molecule mediating homing to peripheral lymphoid organs

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13
Q

CD45R

A

Different forms on all hematopoietic stem cells

Essential in T & B Ag stimulated activation

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14
Q

CD56

A

NK cells, subsets of T cells

Not known
** Most unique marker of NK

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15
Q

CD94

A

NK cells
Subsets of T cells

Subunit of NKG2-A complex involved in inhibition of NK cell cytotoxicity

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