2.4.1 Bordetella spp

Question 1

Virulence factor that facilitate attachment to ciliated epithelial cells

Answer 1

Filamentous Hemagglutinin and Pertactin

Question 2

Virulence factor that interferes to signal transduction and induces chemokines and Cytokines

Answer 2

Pertussis toxin

Question 3

Inhibits early neutrophil recruitment?

Answer 3

Pertussis toxin

Question 4

Inhibits host epithelial and immune effector cells

Answer 4

Adenylate cyclase toxin

Question 5

Causes Ciliostasis and inhibiting DNA synthesis

Answer 5

Tracheal cytotoxin

Question 6

Pertussis is also known as?

Answer 6

Whooping cough

Question 7

What is the incubation for pertussis

Answer 7

7-10 days

Question 8

what are the 3 phases of Pertussis?

Answer 8

Catarrhal phase
Paroxysmal phase
Convalescent phase

Question 9

Phase that is highly communicable, which consist of sneezing, runny nose, mild cough

Answer 9

Catarrhal phase

Question 10

Phase that hase sudden onset of severe repetitive coughing : Whoop

Answer 10

Paroxysmal phase

Question 11

Phase the diminished paroxysmal cough, development of secondary complication such as pneumonia, seizures

Answer 11

Convalescent phase

Question 12

How many weeks does Catarrhal phase last?

Answer 12

1-2 weeks

Question 13

How many weeks does Paroxysmal phase last?

Answer 13

2-4 weeks

Question 14

How many weeks does Convalescent phase last?

Answer 14

3-4 weeks

Question 15

What is the MOT?

Answer 15

Droplets or direct contact

Question 16

Where does it replicate?

Answer 16

Ciliated respiratory epithelial cells