Flashcards in 13 - Atheroma, Thrombosis and Embolism Deck (11):
Commonly affected vessels for atherosclerosis
Circle of willis
Atherosclerosis - pathophysiology
1. endothelial injury
2. hyperlipidaemia accumulation
3. monocytes migrate and ingest lipid forming foam cells (fatty streak)
4. foam cells secrete chemokines
5. smooth cell proliferate and secrete connective tissue
6. atherosclerotic plaque formed
Causes of endothelial injury
immune complex deposition
what is it that attracts monocytes to the intima?
the lipids and endothelial injury cause release of VCAM1
Which wall of artery is this happening in?
Platelets what are they?
Fragments of megakaryocytes in the bone marrow that circulate in blood
What do platelets bind to?
Collagen exposed by endothelial damage and become activated
What do platelets secrete?
Alpha granules - fibrinogen, fibronectin, PDGF
Dense granules - chemotactic chemicals
To do with platelet adhesion and thrombus formation...
Changes in intimal surface of vessel
Pattern of blood flow
Venous thrombosis in relation to virchow's triad
immobile blood flow
More inflammatory mediators (infection, malignancy)