7 - Chronic Inflammation Flashcards Preview

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Flashcards in 7 - Chronic Inflammation Deck (22):
1

Acute inflammation signs

Fast onset
Neutrophil presence
Mild, self-limiting tissue injury
Prominent signs

2

Chronic inflammation signs

Slow onset: days
Subtle signs
Macrophages + lymphocytes
Severe progressive

3

Primary chronic causes - infection

TB, Leprosy, some viruses

4

Primary chronic causes - endogenous materials

Necrotic adipose tissue, uric acid crystals

5

Primary chronic causes - exogenous materials

External origin
Asbestos fibres, sutures, implanted prostheses

6

Primary chronic causes - autoimmune

RA
SLE
Pernicious anaemia

7

Primary chronic causes - primary granulomatous

Crohn's
Sarcoidosis = granulomas collecting in organs

8

Primary chronic causes -

infection
endogenous
exogenous
autoimmune
primary granulomatous

9

Chronic inflammation - morphological features

Infiltration with mononuclear cells (macro, lympho, plasma)
tissue destruction
healing by fibrosis

10

Chronic inflammation - macroscopically

Dependent on the actual disease
Chronic abscess cavity or granulomatous or fibrosis

11

Chronic inflammation - microscopically

cellular infiltrate of lymphocytes, plasma cells and macrophages
exudation if fluid is not prominent
production of new fibrous tissue from granulation tissue

12

Mast cells produce what

Histamine

13

Wound healing involves

Granulation tissue
Angiogenesis
Fibroblasts deposit collagen
Inflammatory cells

14

Granulation tissue is

New connective tissue and blood vessels that form on the surface of a wound during healing

15

Fibrosis is

Formation of excess fibrous connective during repair of damaged tissue

Scarring
Called fibroma if arises from one cell line
Macrophage induced laying down of connective tissue inc. collagen

16

What is a granuloma?

Aggregate (nodule) of epithelioid histiocytes and other cells; lymphocytes and histiocytic giant cells

17

Granulomatous diseases inc.

TB & leprosy

18

What is a histiocytic cell?

Can form where material is indigestible to macrophages e.g. tubercle bacilli which have cell walls resistant to macrophages

19

How do histiocytic cells form?

They're multinucleate giant cells which develop when 2+ macrophages try to engulf same particle.

20

Do all granulomas have giant cells?

No, solitary giant cells in the absence of epithelioid histiocytes is not a granuloma

21

Granulomatous disease

Bacterial - TB, leprosy
Parasitic - schistosomiasis
Fungal - cryptococcus
Synthetic materials - silicosis
Unknown - sarcoidosis, crohn's

22

Histology of granuloma types

Langhans giant cell
Caseous necrosis
Epithelioid macrophages