22 - Behaviour of Tumours Flashcards Preview

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Flashcards in 22 - Behaviour of Tumours Deck (22):
1

Cell to cell adhesion molecules

cadherins

2

cell to matrix adhesion molecules

integrins

3

why is EMT so important

mesenchymal cells are more loosely connected and able to migrate

4

proteolytic enzymes

interstitial collagenases
gelatinases
stomolysins

5

interstitial collagenases degrade

collagen I, II, III

6

gelatinases degrade

collagen IV, gelatin

7

stomolysins degrade

collagen IV, proteoglycans

8

transcoelomic met routes

across peritoneal, pleural, pericardial cavities or in CSF

9

implantation met routes

spillage of tumour during biopsy/surgery

10

carcinomas prefer what met spread

lymphatic spread first

11

sarcomas prefer what spread first

blood spread

12

bones mets go?

breast
prostate
lung
kidney
thyroid

13

transcoelomic met route for

ovarian

14

brain and adrenal go where

lung

15

bone mets can be

lytic (lung) or sclerotic (prostate)

16

stage vs grade

stage - how advanced is the tumour? has the cancer spread? how far?

grade - how aggressive is the tumour? how different does it look from the tissue of origin?

17

TMN system stands for

tumour mets nodes

18

T stage

Tis - in situ disease
T1 5cm
T4 involving skin or chest wall

19

N stage

N0 - no nodes
N1 - ipsilateral nodes
N2 - >node involvement

20

M stage

M0 - no distant mets
M1 - distants mets

21

Dukes Staging for colorectal cancer

A = invades into, but not through bowel wall
B = invades through the bowel wall but with no lymph node mets
C = local lymph nodes involved
D = distant mets

22

Grading looks at

differentiation level
nuclear pleomorphism and size
mitotic activity
necrosis