1.3 Mechanismss of Necrosis Flashcards Preview

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Flashcards in 1.3 Mechanismss of Necrosis Deck (7)
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Mechanisms of Necrosis (6)

(MOM CAP)
Dec ATP
Dec PH
O2 Radicals
Inc ITC Ca++
Inc membrane permeability
Irreversible mitochondrial damage

1

Inc Ca++ causes...(4)q

(PAPE)...leads to membrane damage
Phospholipase
Protease
ATPase
Endonuclease


2

ATPase...

dec atp. no energy not life.

3

Phospholipase

chew up membranes

4

Protease

destroys cytoskeleton and other proteins

5

Endonuclease

Nuclear chromatin damage

6

free radicals

lipid peroxidation