4.9 Clotting Cascade Flashcards Preview

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Flashcards in 4.9 Clotting Cascade Deck (109)
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1

what is the last thing platelets do

secrete PL layer which is important to localize the lesion

2

what else helps localize where you're going to clot

collagen and binding of vonWB

3

how many clotting factors are there

13

4

goal of clotting factors

generate thrombin

5

action of thrombin

cleaves fibrinogen to make fibrin

6

Componets needed for clotting

enzyme, substrate, cofactor (like Ca), and PL surface

7

1

fibrinogen

8

1a

fibrin

9

2

protrhombin

10

2a

thrombin

11

3

tissue factor

12

4

Ca ion

13

5

prothrombin accelerator

14

6

doesn't really exist, is actually just 5a

15

7

proconvertin,
co-thromboplasmin

16

8

antihemophillic factor

17

9

christmas factor

18

10

prothrombinase, stuart prower fac

19

11

thromboplasmin antecedent

20

12

hageman factor

21

13

fibrinase,
fibrin stabilizing factor

22

Intrinsic

12 11 9 -->10 2 1 8

23

Extrinsic

3 7 --> 10 2 1 8

24

Crosstalk areas

7 also to 9, 10 also to 7

25

Extrinsic path begins with

endothlial ijury releaseing 3

26

3 is a cofactor that

complexes with 7 forming 3/7a

27

3/7a activates

10 to 10a (in the same ways as 9a)

28

at the 3/7a step a burst of

thrombin is produced_this is needed early on to form the secondary plug

29

Intrinsic path begins with

exposure of collagen causing a complex of
prekallikrein,
HMW kininogen,
factor 9, and
factor 7 to from

30

Prekallikrein is converted to

kallikrein