2.5 Inflammation and adhesion Flashcards Preview

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Flashcards in 2.5 Inflammation and adhesion Deck (87)
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1

Stimuli for Inflammation

infection,
truama,
physical chemical agents,
necrosis,
foreign bodies,
immune reactions (foreign and auto)

2

features of inflammation

complex,
nonspecific,
mostly vascular and connective tissue reaction to injury,
migration of leukocytes,
systemic reactions,
closely linked to immune system,
coagulation system and repair process

3

Goal of inflammation

to eliminate, dilute or wall off injurious agent, but can be very harmful

4

inflammation overlaps with

immunity,
coagulation,
repair

5

host resistance is divided into

innate and adaptive immunity

6

coagulation system is divided into

dual function of clotting factors and factors as mediators

7

usually inflammation leads to

induction of repair and repair inhibits inflammation. But not always resulting in disease

8

inflammation time course can be

acute or chronic (granulomatous)

9

5 cardinal signs of acute inflammation

rubor, tumor, calor, dolor, functio laesa

10

rubor

redness

11

tumor

swelling

12

calor

heat

13

dolor

pain

14

functio laesa

loss of fn

15

cells of inflammation

neutorphil, basophil, platelet, eosinophil, monocyte/macrophage, lymphocyte, plasma cell

16

neutrophil

poly or PMN (many lobed nucleus) seen in acute inflammation

17

basophil

accute/allergic - dark granules

18

platelet

acute

19

eosinophil

chronic/allergic

20

monocyte/macrophage

chronic - kidney shaped nucleus

21

lymphocyte

chronic - little bigger than a red cell

22

plasmacell

chronic - eccentric nucleus filled with mrna for Ig

23

difference btw eosinophil and mast cell

eosinophil will be red granules and mast cell will be purpleish

24

band form

immature neutrophil looks like a wll defined horse shoe - not normal to have lots - tells you there is overproduction

25

other cells also important for inflammatory process

fibroblasts

26

simple demonstration of inflammatory response

wheal and flare reaction

27

first thing when you scrape arm

goes white due to vasoconstriction of arteries and arterioles

28

why does the white scratch turn red

you induced an inflammatory response so there is hyperemia as more blood rushes there

29

what governs efflux and influx of fluid in vessels

mediators - inflammation gets things out of the vessels where you need them,
they don_t have to be damaged and leaky bc the mediators will direct them

30

transudate

fluid accumulation in body cavity with low protein/specific gravity - ultrafiltrate - i.e. water squeezed out of vessels