Path 1.2 Necrosis Flashcards Preview

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Flashcards in Path 1.2 Necrosis Deck (10):
1

types of necrosis

coagulative,
liquifactive,
caseous,
fat,
fibrinoid,
gangrenous

2

coagulative

preservation of cell outlines of dead cells,
intense staining with eosin, more eosin binding sites bc the cell is dying

3

liquifactive necrosis

tissue turns to liquid

4

liquifactive necrosis etiology

occurs in absess (liquid-pus--a collection of neutrophils),
also occurs in the CNS (bc the brain when its injured does everything it can to maintain its 3D structure - surrounding brain tissue froms a gliosis to try and keep the 3D structure in the brain - by forming scars

5

caseous necrosis

cheese-like (cream cheese)

6

caseous necrosis etiology

majority is due to granulomas inflammation and TB.
Some fungi can also form this, this is the macrophages forming this by releasing cytokines that kill the tissue in the particular area

7

fat necrosis

chalky white lesion - you get soaponification of fat liberating the fatty acid that react with calcium to form calcium salts in fatty acid.
Drop in calcium concentration is something you would see in fat necrosis

8

fat necrosis example

injury to pancreas and it releases enzymes like lipases,
the lipases react with the fatty deposits in the omentum

9

ex 2 of fat necrosis

fatty area of the body subjected to trauma
-->whole area of fat dies and just goes away

10

Fibrinoid necrosis

walls of organs, bc of damage to the vessles. Caused by malignant hypertension and vasculitis due to increased permeability of vessel walls