Local Anesthetics

Question 1

LA can bind to the voltage-gated sodium channel when it is in what state?

Answer 1

Active and inactive states

Question 2

_____ regulates resting membrane potential

Answer 2

Potassium

Question 3

_____ regulates threshold potential

Answer 3

Calcium

Question 4

Answer 4

Question 5

What order in vivo do LA inhibit peripheral nerves (first to last)

Answer 5

B fibers
C fibers
A delta fibers
A alpha fibers

Question 6

Which LA is a/w neurotoxicity in spinal anesthesia?

Answer 6

Chloroprocaine

Question 7

Which LA is least protein bound?

Answer 7

Chloroprocaine

Question 8

Answer 8

Question 9

What is the only unionized LA at physiologic pH?

Answer 9

Benzocaine (pKa 3.5)

Question 10

Saltatory conduction occurs in all of the following nerve types EXCEPT?
A gamma fibers
A delta fibers
B fibers
C fibers

Answer 10

C fibers

Question 11

Max dose of cocaine

Answer 11

1.5-3.0 mg/kg or 150-200mg

Question 12

How many mL of 0.5% bupivacaine can be safely injected into a child weighing 35 kg?

Answer 12

17.5 mL

Question 13

What is the dose range for cocaine?

Answer 13

1.5-3.0 mg/kg (not to exceed 200mg)